PDF(Pubmed)
Abstract：
UNASSIGNED: The aim of this study was to investigate the effect of antibiotic treatment for chronic endometritis (CE) on reproductive outcomes.
UNASSIGNED: Systematic review and meta-analysis.
UNASSIGNED: Women with reproductive failures, including recurrent implantation failure (RIF), and recurrent pregnancy loss (RPL).
UNASSIGNED: Literature searches were performed using three electronic databases (PubMed, Embase, and Web of Science) until 1 December 2021 (without date restriction). The following comparators were included: women with CE receiving antibiotics vs. untreated controls; women with cured CE vs. women with normal endometrial histology (negative for CE); and women with cured CE vs. women with persistent CE (PCE). The summary measures were indicated as odds ratio (OR) with a 95% confidence interval (CI).
UNASSIGNED: These include on-going pregnancy rate/live birth rate (OPR/LBR), clinical pregnancy rate (CPR), and miscarriage rate/pregnancy loss rate (MR/PLR).
UNASSIGNED: A total of 2,154 women (from twelve studies) were enrolled. Compared with the control group, women with CE receiving antibiotics did not show a statistically significant difference in OPR/LBR (P = 0.09) and CPR (P = 0.36), although there was a lower MR (P = 0.03). Women with cured CE have higher OPR/LBR (OR 1.57) and CPR (OR 1.56) in comparison with those with non-CE. There was a statistically significantly higher OPR/LBR (OR 6.82, P < 0.00001) and CPR (OR 9.75, P < 0.00001) in women with cured CE vs. those with persistent CE.
UNASSIGNED: While antibiotic treatment is a sensible option to cure CE, more well-designed prospective studies are needed to evaluate the reproductive impact of antibiotic treatment. Cured CE provides high-quality maternal conditions for subsequent embryo transfer and successful pregnancy.
UNASSIGNED: Systematic review and meta-analysis.
UNASSIGNED: Women with reproductive failures, including recurrent implantation failure (RIF), and recurrent pregnancy loss (RPL).
UNASSIGNED: Literature searches were performed using three electronic databases (PubMed, Embase, and Web of Science) until 1 December 2021 (without date restriction). The following comparators were included: women with CE receiving antibiotics vs. untreated controls; women with cured CE vs. women with normal endometrial histology (negative for CE); and women with cured CE vs. women with persistent CE (PCE). The summary measures were indicated as odds ratio (OR) with a 95% confidence interval (CI).
UNASSIGNED: These include on-going pregnancy rate/live birth rate (OPR/LBR), clinical pregnancy rate (CPR), and miscarriage rate/pregnancy loss rate (MR/PLR).
UNASSIGNED: A total of 2,154 women (from twelve studies) were enrolled. Compared with the control group, women with CE receiving antibiotics did not show a statistically significant difference in OPR/LBR (P = 0.09) and CPR (P = 0.36), although there was a lower MR (P = 0.03). Women with cured CE have higher OPR/LBR (OR 1.57) and CPR (OR 1.56) in comparison with those with non-CE. There was a statistically significantly higher OPR/LBR (OR 6.82, P < 0.00001) and CPR (OR 9.75, P < 0.00001) in women with cured CE vs. those with persistent CE.
UNASSIGNED: While antibiotic treatment is a sensible option to cure CE, more well-designed prospective studies are needed to evaluate the reproductive impact of antibiotic treatment. Cured CE provides high-quality maternal conditions for subsequent embryo transfer and successful pregnancy.
摘要：
未经授权：本研究的目的是研究抗生素治疗慢性子宫内膜炎（CE）对生殖结局的影响。
未经评估：系统评价和荟萃分析。
未经批准：有生殖障碍的妇女，包括复发性植入失败（RIF），和复发性妊娠丢失（RPL）。
UNASSIGNED：使用三个电子数据库（PubMed，Embase,和WebofScience)至2021年12月1日(无日期限制)。包括以下比较：接受抗生素治疗的CE女性与未经治疗的对照；CE治愈的女性与子宫内膜组织学正常的女性（CE阴性）；治愈的女性与女性持续性CE（PCE）。汇总指标表示为比值比（OR），置信区间为95％（CI）。
未经评估：这些包括持续怀孕率/活产率（OPR/LBR），临床妊娠率（CPR），和流产率/妊娠损失率（MR/PLR）。
UNASSIGNED：共有2,154名妇女（来自12项研究）入组。与对照组相比,接受抗生素治疗的女性在OPR/LBR（P=0.09）和CPR（P=0.36）方面没有统计学上的显着差异，尽管MR较低（P=0.03）。与非CE患者相比，治愈CE的女性具有更高的OPR/LBR（OR1.57）和CPR（OR1.56）。治愈CE的女性与女性相比，OPR/LBR（OR6.82，P<0.00001）和CPR（OR9.75，P<0.00001）在统计学上明显更高。那些具有持久性的CE。
未经批准：虽然抗生素治疗是治愈CE的明智选择，需要更精心设计的前瞻性研究来评估抗生素治疗对生殖的影响.治愈的CE为随后的胚胎移植和成功怀孕提供了高质量的母体条件。
未经评估：系统评价和荟萃分析。
未经批准：有生殖障碍的妇女，包括复发性植入失败（RIF），和复发性妊娠丢失（RPL）。
UNASSIGNED：使用三个电子数据库（PubMed，Embase,和WebofScience)至2021年12月1日(无日期限制)。包括以下比较：接受抗生素治疗的CE女性与未经治疗的对照；CE治愈的女性与子宫内膜组织学正常的女性（CE阴性）；治愈的女性与女性持续性CE（PCE）。汇总指标表示为比值比（OR），置信区间为95％（CI）。
未经评估：这些包括持续怀孕率/活产率（OPR/LBR），临床妊娠率（CPR），和流产率/妊娠损失率（MR/PLR）。
UNASSIGNED：共有2,154名妇女（来自12项研究）入组。与对照组相比,接受抗生素治疗的女性在OPR/LBR（P=0.09）和CPR（P=0.36）方面没有统计学上的显着差异，尽管MR较低（P=0.03）。与非CE患者相比，治愈CE的女性具有更高的OPR/LBR（OR1.57）和CPR（OR1.56）。治愈CE的女性与女性相比，OPR/LBR（OR6.82，P<0.00001）和CPR（OR9.75，P<0.00001）在统计学上明显更高。那些具有持久性的CE。
未经批准：虽然抗生素治疗是治愈CE的明智选择，需要更精心设计的前瞻性研究来评估抗生素治疗对生殖的影响.治愈的CE为随后的胚胎移植和成功怀孕提供了高质量的母体条件。
