PDF(Pubmed)
Abstract：
Pharmacoresistant epilepsy poses a great burden to patients, their families, and the whole healthcare system, with numerous social, economic, physical, and psychical consequences. Hence, it is a diagnosis that has to be made only in cases of high certainty, after all potential causes of epilepsy have been evaluated. One of the important causes of pharmacoresistant epilepsy is false pharmacoresistance, an entity that implies a condition in which poor disease control is not a consequence of the biology of the disease itself, antiepileptic drug inefficacy, and/or patient specificity. It is a consequence of human error and strongly depends on the experience of the treating physician, as well as on the attitude of the patient. Despite its \'falseness\', this entity is accompanied by real consequences for the patient and his family, and at the same time, it delays appropriate treatment of the actual disease from which the patient is suffering. In order to introduce appropriate treatment and avoid unnecessary and harmful diagnostic procedures, false pharmacoresistance is a condition that has to be ruled out in any patient with difficult-to-treat seizures.
摘要：
耐药性癫痫给患者带来了巨大的负担，他们的家人,整个医疗系统，与众多的社会,经济,物理，和心理后果。因此，这是一个只有在高度确定的情况下才能做出的诊断，在评估了所有癫痫的潜在原因后。药物抗性癫痫的重要原因之一是假药物抗性,一种实体，意味着疾病控制不佳不是疾病本身生物学的结果，抗癫痫药无效，和/或患者特异性。这是人为错误的结果，在很大程度上取决于治疗医生的经验，以及病人的态度。尽管它的“虚假”，这个实体伴随着对患者及其家人的实际后果，同时,它延迟了对患者所遭受的实际疾病的适当治疗。为了引入适当的治疗并避免不必要和有害的诊断程序，在任何难以治疗的癫痫患者中，假药物耐药性是一种必须排除的疾病。
