PDF(Pubmed)
Abstract：
UNASSIGNED: Type 1 diabetes mellitus (T1DM) is a well-known autoimmune disease, characterized by β-cell destruction in pancreas islet cells, which results insulin deficiency and subsequent hyperglycemic sequelae. While there is screening for type 2 DM that leads to better glycemic control and outcome, the majority of T1DM patients are diagnosed when much of the pancreatic cells and their function are disturbed. The aim of this article is to present an overview of the effective factors in the positivity of Glutamic acid decarboxylase antibody )GADA( and identifying the high-risk individuals for T1DM.
UNASSIGNED: We searched English literature available at National Library of Medicine via PubMed, and Google Scholar through December 2020. Finally, 79 papers have been included in the study. Studies were summarized based on the number of positive autoantibodies and onset of T1DM over time and GADA correlation with different variables.
UNASSIGNED: GADA is an easy marker to measure that can be detected many months prior to the clinical presentation and remains positive even after early childhood.
UNASSIGNED: We searched English literature available at National Library of Medicine via PubMed, and Google Scholar through December 2020. Finally, 79 papers have been included in the study. Studies were summarized based on the number of positive autoantibodies and onset of T1DM over time and GADA correlation with different variables.
UNASSIGNED: GADA is an easy marker to measure that can be detected many months prior to the clinical presentation and remains positive even after early childhood.
摘要：
未经证实：1型糖尿病（T1DM）是一种众所周知的自身免疫性疾病，以胰岛细胞中的β细胞破坏为特征，导致胰岛素缺乏和随后的高血糖后遗症。虽然有筛查2型糖尿病，导致更好的血糖控制和结果，大多数T1DM患者是在胰腺细胞及其功能受到干扰时被诊断出来的.本文的目的是概述谷氨酸脱羧酶抗体GADA阳性的有效因素（以及确定T1DM的高危个体）。
UASSIGNED：我们通过PubMed搜索了国家医学图书馆的英文文献，和谷歌学者到2020年12月。最后,79篇论文被纳入研究。根据阳性自身抗体的数量和T1DM随时间的发作以及GADA与不同变量的相关性对研究进行了总结。
UNASSIGNED：GADA是一种易于测量的标记，可以在临床表现前数月检测到，甚至在儿童早期仍保持阳性。
UASSIGNED：我们通过PubMed搜索了国家医学图书馆的英文文献，和谷歌学者到2020年12月。最后,79篇论文被纳入研究。根据阳性自身抗体的数量和T1DM随时间的发作以及GADA与不同变量的相关性对研究进行了总结。
UNASSIGNED：GADA是一种易于测量的标记，可以在临床表现前数月检测到，甚至在儿童早期仍保持阳性。
