PDF(Pubmed)
Abstract：
The aim of this study was to characterize and compare changes in subcutaneous fat in the malar, brachial and crural region in a cohort of HIV-infected patients taking antiretroviral therapy. This prospective longitudinal study included 77 patients who were selected from the initial cohort evaluated in 2007 and 2008. We examined reversibility of lipoatrophy measured by ultrasound over at least five-year period and factors related to its reversibility. All 46 patients who used stavudine switched from stavudine to another combination. Of 58 patients on zidovudine, 16 (28%) were on a zidovudine based regimen at the second follow up. There was evidence for subcutaneous fat increase in the malar area (p<0.001) and no increase in the brachial and crural areas. Patients who were smokers and had poor adherence to the Mediterranean diet had a thinner malar area at the follow up measurement (p=0.030) and smaller increase in subcutaneous malar fat compared to others (p=0.040). Our study suggested that modest increase of subcutaneous fat in malar area coincided with stopping stavudine and fewer usage of zidovudine. Lifestyle with non-adherence to the Mediterranean diet and smoking were associated with a smaller increase in subcutaneous malar fat.
摘要：
这项研究的目的是表征和比较在皮下脂肪的变化，在接受抗逆转录病毒治疗的HIV感染患者队列中，肱和脚区域。这项前瞻性纵向研究包括从2007年和2008年评估的初始队列中选择的77名患者。我们检查了至少五年内通过超声测量的脂肪萎缩的可逆性以及与其可逆性相关的因素。所有使用司他夫定的46例患者都从司他夫定切换到另一种组合。在服用齐多夫定的58例患者中，在第二次随访时，16人（28％）采用基于齐多夫定的方案。有证据表明，小腿区皮下脂肪增加（p<0.001），而肱和小腿区没有增加。与其他患者相比，吸烟者和坚持地中海饮食的患者在随访测量中的小腿面积较薄（p=0.030），皮下小腿脂肪的增加较小（p=0.040）。我们的研究表明，面部皮下脂肪的适度增加与停止司他夫定和较少使用齐多夫定同时发生。不遵守地中海饮食和吸烟的生活方式与皮下脂肪的较小增加有关。
