Abstract：
Anti-IgLON5 is a rare neurologic disease that can present with epileptic seizures. However, epileptic seizures have not been characterized and are underreported. We aimed to investigate the clinical characteristics and demographics of epileptic seizures in patients with anti-IgLON5 disease.
We reported a case of anti-IgLON5 disease presenting with epileptic seizures and presented a comprehensive literature review on epileptic seizures in patients with the anti-IgLON5 disease. We searched the Medline, Pubmed, and Web of Science databases using the following search algorithm: \"IgLON5\" or \"anti-IgLON5\" or \"IgLON5 antibody\" limited to publications in English.
We identified 183 cases from 66 publications. In addition to our case, nine (4.9%) patients with anti-IgLON5 disease had reported epileptic seizures, either focal or generalized. Of those, epileptic seizures were one of the main reasons for neurology consultation in six (3.2%). Patients with epileptic seizures affected both sexes similarly and usually developed in middle age. In addition to epileptic seizures, a majority of patients had sleep disorders and cognitive impairment. The frequency of epileptic seizures was reduced with the treatment of immunotherapy and antiseizure medication.
Anti-IgLON5 disease can present with epileptic seizures, and our study expands the clinical spectrum of the anti-IgLON5 disease.
We reported a case of anti-IgLON5 disease presenting with epileptic seizures and presented a comprehensive literature review on epileptic seizures in patients with the anti-IgLON5 disease. We searched the Medline, Pubmed, and Web of Science databases using the following search algorithm: \"IgLON5\" or \"anti-IgLON5\" or \"IgLON5 antibody\" limited to publications in English.
We identified 183 cases from 66 publications. In addition to our case, nine (4.9%) patients with anti-IgLON5 disease had reported epileptic seizures, either focal or generalized. Of those, epileptic seizures were one of the main reasons for neurology consultation in six (3.2%). Patients with epileptic seizures affected both sexes similarly and usually developed in middle age. In addition to epileptic seizures, a majority of patients had sleep disorders and cognitive impairment. The frequency of epileptic seizures was reduced with the treatment of immunotherapy and antiseizure medication.
Anti-IgLON5 disease can present with epileptic seizures, and our study expands the clinical spectrum of the anti-IgLON5 disease.
摘要：
抗IgLON5是一种罕见的神经系统疾病，可伴有癫痫发作。然而,癫痫发作没有被定性和漏报。我们旨在研究抗IgLON5病患者癫痫发作的临床特征和人口统计学。
我们报道了一例出现癫痫发作的抗IgLON5疾病，并对抗IgLON5疾病患者的癫痫发作进行了全面的文献综述。我们搜查了Medline,Pubmed,和WebofScience数据库使用以下搜索算法：“IgLON5”或“抗IgLON5”或“IgLON5抗体”仅限于英文出版物。
我们从66篇出版物中确定了183例病例。除了我们的案子,9例（4.9%）抗IgLON5病患者报告癫痫发作，无论是焦点还是广义。其中,癫痫发作是6例(3.2%)神经内科咨询的主要原因之一。癫痫发作的患者对两性的影响相似，通常在中年发展。除了癫痫发作,大多数患者有睡眠障碍和认知障碍.通过免疫疗法和抗癫痫药物治疗，癫痫发作的频率降低。
抗-IgLON5疾病可伴有癫痫发作，我们的研究扩展了抗IgLON5疾病的临床范围。
我们报道了一例出现癫痫发作的抗IgLON5疾病，并对抗IgLON5疾病患者的癫痫发作进行了全面的文献综述。我们搜查了Medline,Pubmed,和WebofScience数据库使用以下搜索算法：“IgLON5”或“抗IgLON5”或“IgLON5抗体”仅限于英文出版物。
我们从66篇出版物中确定了183例病例。除了我们的案子,9例（4.9%）抗IgLON5病患者报告癫痫发作，无论是焦点还是广义。其中,癫痫发作是6例(3.2%)神经内科咨询的主要原因之一。癫痫发作的患者对两性的影响相似，通常在中年发展。除了癫痫发作,大多数患者有睡眠障碍和认知障碍.通过免疫疗法和抗癫痫药物治疗，癫痫发作的频率降低。
抗-IgLON5疾病可伴有癫痫发作，我们的研究扩展了抗IgLON5疾病的临床范围。
