We reported a case of anti-IgLON5 disease presenting with epileptic seizures and presented a comprehensive literature review on epileptic seizures in patients with the anti-IgLON5 disease. We searched the Medline, Pubmed, and Web of Science databases using the following search algorithm: \"IgLON5\" or \"anti-IgLON5\" or \"IgLON5 antibody\" limited to publications in English.
We identified 183 cases from 66 publications. In addition to our case, nine (4.9%) patients with anti-IgLON5 disease had reported epileptic seizures, either focal or generalized. Of those, epileptic seizures were one of the main reasons for neurology consultation in six (3.2%). Patients with epileptic seizures affected both sexes similarly and usually developed in middle age. In addition to epileptic seizures, a majority of patients had sleep disorders and cognitive impairment. The frequency of epileptic seizures was reduced with the treatment of immunotherapy and antiseizure medication.
Anti-IgLON5 disease can present with epileptic seizures, and our study expands the clinical spectrum of the anti-IgLON5 disease.
我们报道了一例出现癫痫发作的抗IgLON5疾病,并对抗IgLON5疾病患者的癫痫发作进行了全面的文献综述。我们搜查了Medline,Pubmed,和WebofScience数据库使用以下搜索算法:“IgLON5”或“抗IgLON5”或“IgLON5抗体”仅限于英文出版物。
我们从66篇出版物中确定了183例病例。除了我们的案子,9例(4.9%)抗IgLON5病患者报告癫痫发作,无论是焦点还是广义。其中,癫痫发作是6例(3.2%)神经内科咨询的主要原因之一。癫痫发作的患者对两性的影响相似,通常在中年发展。除了癫痫发作,大多数患者有睡眠障碍和认知障碍.通过免疫疗法和抗癫痫药物治疗,癫痫发作的频率降低。
抗-IgLON5疾病可伴有癫痫发作,我们的研究扩展了抗IgLON5疾病的临床范围。