作为 PPM1A 激活剂的米替福辛通过经由小胶质细胞 / 神经元串扰减轻 tau 病变来改善小鼠的 AD 样病理。
关键词: AAV, Adeno-associated virus AD, Alzheimer's disease ALP, Alkaline phosphatase ALT, Alanine aminotransferase AST, Aspartate aminotransferase Akt, V-akt routine thymoma viral oncogene homolog Alzheimer's disease Aβ, Amyloid-β CDK5, Cyclin-dependent protein kinase-5 CNS, Central nervous system CX3CR1 CX3CR1, C-X3-C Motif Chemokine Receptor 1 CaMKII, Calcium/calmodulin-dependent protein kinase II DYRK1A, Dual-specificity tyrosine phosphorylation-regulated kinase-1A GSK3β, Glycogen synthase kinase 3β LTP, Long-term potentiation MST, Microscale thermophoresis MWM, Morris water maze Miltefosine NF-kB, Nuclear factor-κb NFTs, Neurofibrillary tangles NLRP3 NLRP3, Nod-like receptor protein 3 NOR, New object recognition PP2, Protein phosphatase 2 PPM1A PPM1A, Phosphatase magnesium-dependent 1A PSD95, Postsynaptic density protein 95 SYN, Synaptophysin Tauopathy fEPSPs, Field excitatory postsynaptic potentials
来 源:
DOI:10.1016/j.bbih.2022.100546
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