PDF(Pubmed)
Abstract：
UNASSIGNED: The potential for cartilage repair using articular cartilage derived chondroprogenitors has recently gained popularity due to promising results from in-vitro and in-vivo studies. Translation of results from in-vitro to a clinical setting requires a sufficient number of animal studies displaying significant positive outcomes. Thus, this systematic review comprehensively discusses the available literature (January 2000-March 2022) on animal models employing chondroprogenitors for cartilage regeneration, highlighting the results and limitations associated with their use.As per Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, a web-based search of PubMed and SCOPUS databases was performed for the following terminologies: \"chondroprogenitors\", \"cartilage-progenitors\", and \"chondrogenic-progenitors\", which yielded 528 studies. A total of 12 studies met the standardized inclusion criteria, which included chondroprogenitors derived from hyaline cartilage isolated using fibronectin adhesion assay (FAA) or migratory assay from explant cultures, further analyzing the role of chondroprogenitors using in-vivo animal models.
UNASSIGNED: Analysis revealed that FAA chondroprogenitors demonstrated the ability to attenuate osteoarthritis, repair chondral defects and form stable cartilage in animal models. They displayed better outcomes than bone marrow-derived mesenchymal stem cells but were comparable to chondrocytes. Migratory chondroprogenitors also demonstrated superiority to BM-MSCs in terms of higher chondrogenesis and lower hypertrophy, although a direct comparison to FAA-CPs and other cell types is warranted.
UNASSIGNED: Chondroprogenitors exhibit superior properties for chondrogenic repair; however, limited data on animal studies necessitates further studies to optimize their use before clinical translation for neo-cartilage formation.
UNASSIGNED: Analysis revealed that FAA chondroprogenitors demonstrated the ability to attenuate osteoarthritis, repair chondral defects and form stable cartilage in animal models. They displayed better outcomes than bone marrow-derived mesenchymal stem cells but were comparable to chondrocytes. Migratory chondroprogenitors also demonstrated superiority to BM-MSCs in terms of higher chondrogenesis and lower hypertrophy, although a direct comparison to FAA-CPs and other cell types is warranted.
UNASSIGNED: Chondroprogenitors exhibit superior properties for chondrogenic repair; however, limited data on animal studies necessitates further studies to optimize their use before clinical translation for neo-cartilage formation.
摘要：
UNASSIGNED：由于体外和体内研究的有希望的结果，使用关节软骨衍生的软骨祖细胞进行软骨修复的潜力最近得到了普及。将结果从体外转化为临床设置需要足够数量的动物研究显示出显著的积极结果。因此，本系统综述全面讨论了使用软骨祖细胞进行软骨再生的动物模型（2000年1月至2022年3月）的现有文献，突出显示与使用相关的结果和限制。根据系统审查和荟萃分析指南的首选报告项目，对PubMed和SCOPUS数据库进行了基于网络的搜索，搜索了以下术语：“软骨祖细胞”，“软骨祖细胞”，和“软骨形成祖细胞”，共进行了528项研究。共有12项研究符合标准化纳入标准，其中包括使用纤连蛋白粘附测定法（FAA）或外植体培养物的迁移测定法分离的透明软骨的软骨祖细胞，使用体内动物模型进一步分析软骨祖细胞的作用。
UNASSIGNED：分析表明，FAA软骨祖细胞具有减轻骨关节炎的能力，在动物模型中修复软骨缺损并形成稳定的软骨。它们显示出比骨髓来源的间充质干细胞更好的结果，但与软骨细胞相当。迁移软骨祖细胞在软骨形成较高和肥大较低方面也比BM-MSCs优越。尽管有必要与FAA-CP和其他细胞类型进行直接比较。
UNASSIGNED：软骨祖细胞表现出优越的软骨修复特性；然而，有限的动物研究数据需要进一步的研究,以优化它们的使用,然后临床转化为新软骨形成.
UNASSIGNED：分析表明，FAA软骨祖细胞具有减轻骨关节炎的能力，在动物模型中修复软骨缺损并形成稳定的软骨。它们显示出比骨髓来源的间充质干细胞更好的结果，但与软骨细胞相当。迁移软骨祖细胞在软骨形成较高和肥大较低方面也比BM-MSCs优越。尽管有必要与FAA-CP和其他细胞类型进行直接比较。
UNASSIGNED：软骨祖细胞表现出优越的软骨修复特性；然而，有限的动物研究数据需要进一步的研究,以优化它们的使用,然后临床转化为新软骨形成.
