PDF(Pubmed)
Abstract：
UNASSIGNED: Biotin is a water-soluble vitamin acting as a covalently bound coenzyme in regulating energy production. Previous studies have reported that biotin supplementation may influence blood glucose and lipid level in patients with type 2 diabetes mellitus (T2DM).
UNASSIGNED: We searched Pubmed, Embase, and Cochrane library databases up to 8th August 2022 for studies examining the effects of biotin supplementation in T2DM patients. Pooled effects were measured by weighted mean differences (WMDs) with 95% confidence intervals (CI) using random effects models. Inter-study heterogeneity was assessed and quantified.
UNASSIGNED: A total of five random controlled trials (RCT), involving 445 participants were included. It was suggested that biotin supplementation for 28 to 90 days significantly decreased the level of fasting blood glucose (FBG) (MD: -1.21 mmol/L, 95% CI: -2.73 to 0.31), total cholesterol (TC) (MD: -0.22 mmol/L, 95% CI: -0.25 to -0.19) and triglycerides (TG) (MD: -0.59 mmol/L, 95% CI: -1.21 to 0.03). No significant beneficial effects were observed on insulin (MD: 1.88 pmol/L 95% CI: -13.44 to 17.21). Evidence for the impact of biotin supplementation on the levels of glycated hemoglobin (HbA1c), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) and very low-density lipoprotein cholesterol (VLDL-C) was limited to draw conclusion.
UNASSIGNED: Biotin supplementation may decrease FBG, TC and TG levels. However, its influence on insulin is not significant and further studies on the effects of biotin on HbA1c, LDL-C, HDL-C and VLDL-C are expected.
UNASSIGNED: We searched Pubmed, Embase, and Cochrane library databases up to 8th August 2022 for studies examining the effects of biotin supplementation in T2DM patients. Pooled effects were measured by weighted mean differences (WMDs) with 95% confidence intervals (CI) using random effects models. Inter-study heterogeneity was assessed and quantified.
UNASSIGNED: A total of five random controlled trials (RCT), involving 445 participants were included. It was suggested that biotin supplementation for 28 to 90 days significantly decreased the level of fasting blood glucose (FBG) (MD: -1.21 mmol/L, 95% CI: -2.73 to 0.31), total cholesterol (TC) (MD: -0.22 mmol/L, 95% CI: -0.25 to -0.19) and triglycerides (TG) (MD: -0.59 mmol/L, 95% CI: -1.21 to 0.03). No significant beneficial effects were observed on insulin (MD: 1.88 pmol/L 95% CI: -13.44 to 17.21). Evidence for the impact of biotin supplementation on the levels of glycated hemoglobin (HbA1c), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) and very low-density lipoprotein cholesterol (VLDL-C) was limited to draw conclusion.
UNASSIGNED: Biotin supplementation may decrease FBG, TC and TG levels. However, its influence on insulin is not significant and further studies on the effects of biotin on HbA1c, LDL-C, HDL-C and VLDL-C are expected.
摘要：
未经授权：生物素是一种水溶性维生素，在调节能量产生中充当共价结合的辅酶。先前的研究报道，补充生物素可能会影响2型糖尿病（T2DM）患者的血糖和血脂水平。
未经授权：我们搜索了Pubmed，Embase,以及截至2022年8月8日的Cochrane图书馆数据库，用于研究补充生物素对T2DM患者的影响。使用随机效应模型通过加权平均差异（WMD）和95％置信区间（CI）测量集合效应。评估和量化研究间异质性。
未经评估：共有5项随机对照试验（RCT），纳入了445名参与者.提示补充生物素28至90天显着降低空腹血糖（FBG）水平（MD：-1.21mmol/L，95%CI：-2.73至0.31），总胆固醇（TC）（MD：-0.22mmol/L，95%CI：-0.25至-0.19）和甘油三酯（TG）（MD：-0.59mmol/L，95%CI：-1.21~0.03）。未观察到对胰岛素的显著有益作用(MD:1.88pmol/L95%CI:-13.44至17.21)。补充生物素对糖化血红蛋白（HbA1c）水平的影响的证据，低密度脂蛋白胆固醇（LDL-C），高密度脂蛋白胆固醇（HDL-C）和极低密度脂蛋白胆固醇（VLDL-C）有限得出结论。
未经证实：补充生物素可能会降低FBG，TC和TG水平。然而,其对胰岛素的影响不显著，进一步研究生物素对HbA1c的影响，LDL-C,HDL-C和VLDL-C是预期的。
未经授权：我们搜索了Pubmed，Embase,以及截至2022年8月8日的Cochrane图书馆数据库，用于研究补充生物素对T2DM患者的影响。使用随机效应模型通过加权平均差异（WMD）和95％置信区间（CI）测量集合效应。评估和量化研究间异质性。
未经评估：共有5项随机对照试验（RCT），纳入了445名参与者.提示补充生物素28至90天显着降低空腹血糖（FBG）水平（MD：-1.21mmol/L，95%CI：-2.73至0.31），总胆固醇（TC）（MD：-0.22mmol/L，95%CI：-0.25至-0.19）和甘油三酯（TG）（MD：-0.59mmol/L，95%CI：-1.21~0.03）。未观察到对胰岛素的显著有益作用(MD:1.88pmol/L95%CI:-13.44至17.21)。补充生物素对糖化血红蛋白（HbA1c）水平的影响的证据，低密度脂蛋白胆固醇（LDL-C），高密度脂蛋白胆固醇（HDL-C）和极低密度脂蛋白胆固醇（VLDL-C）有限得出结论。
未经证实：补充生物素可能会降低FBG，TC和TG水平。然而,其对胰岛素的影响不显著，进一步研究生物素对HbA1c的影响，LDL-C,HDL-C和VLDL-C是预期的。
