Abstract：
OBJECTIVE: To report a case of idiopathic lipid keratopathy in a normolipemic cat.
METHODS: A 10-year-old neutered female European domestic cat.
RESULTS: A cat was evaluated for bilateral white corneal deposits. Slit-lamp examination revealed multiple, well-defined, round, stromal, cream-colored deposits of different sizes associated with generalized superficial corneal vascularization. Blood lipids were normal, and no history of travel to tropical locations or ocular trauma was present. Topical betamethasone/gentamicin 0.1% suspension q 12 hours did not result in any improvement of clinical appearance after one week. Tomography following the initial therapy revealed dense, hyperreflective deposits with posterior shadowing in the anterior and mid stroma of both corneas. A four-week course of itraconazole 0.01% ophthalmic cream was prescribed q 12 hours with no improvement. Four months after the initial examination, a diagnostic superficial keratectomy and amniotic membrane implantation were performed. Histopathological analysis showed membrane bound vacuoles with infiltration of foamy macrophages suggesting a diagnosis of primary lipidosis. The post-surgical period was unremarkable, and ten days later, the patient was re-examined. Opacification from a corneal leukoma was observed in the excision site with mild fibrotic tissue. Two months post-keratectomy, no further changes were detected in the cornea, and the patient was managed only with topical lubricant.
CONCLUSIONS: To our knowledge, this is the first report of idiopathic corneal lipidosis in a cat and may be considered as a differential diagnosis of corneal disease in felines.
METHODS: A 10-year-old neutered female European domestic cat.
RESULTS: A cat was evaluated for bilateral white corneal deposits. Slit-lamp examination revealed multiple, well-defined, round, stromal, cream-colored deposits of different sizes associated with generalized superficial corneal vascularization. Blood lipids were normal, and no history of travel to tropical locations or ocular trauma was present. Topical betamethasone/gentamicin 0.1% suspension q 12 hours did not result in any improvement of clinical appearance after one week. Tomography following the initial therapy revealed dense, hyperreflective deposits with posterior shadowing in the anterior and mid stroma of both corneas. A four-week course of itraconazole 0.01% ophthalmic cream was prescribed q 12 hours with no improvement. Four months after the initial examination, a diagnostic superficial keratectomy and amniotic membrane implantation were performed. Histopathological analysis showed membrane bound vacuoles with infiltration of foamy macrophages suggesting a diagnosis of primary lipidosis. The post-surgical period was unremarkable, and ten days later, the patient was re-examined. Opacification from a corneal leukoma was observed in the excision site with mild fibrotic tissue. Two months post-keratectomy, no further changes were detected in the cornea, and the patient was managed only with topical lubricant.
CONCLUSIONS: To our knowledge, this is the first report of idiopathic corneal lipidosis in a cat and may be considered as a differential diagnosis of corneal disease in felines.
摘要：
目的：报道1例正常血脂猫特发性脂质角膜病。
方法：一只10岁的雌性欧洲家猫。
结果：评估一只猫的双侧白色角膜沉积。裂隙灯检查显示多个，定义明确，圆形,基质,与广泛性浅表角膜血管形成相关的不同大小的奶油色沉积物。血脂正常,没有前往热带地区或眼外伤的病史。在12小时内局部使用倍他米松/庆大霉素0.1%混悬液,一周后没有导致临床外观的任何改善。初始治疗后的体层摄影术显示密集，在两个角膜的前和中基质中具有后阴影的高反射沉积物。在12小时内开出为期四周的伊曲康唑0.01％眼霜疗程，无改善。初检四个月后,进行了诊断性浅表角膜切除术和羊膜植入术.组织病理学分析显示膜结合的液泡，泡沫巨噬细胞浸润，提示诊断为原发性脂肪增多。手术后的时期并不明显，十天后,患者被重新检查。在具有轻度纤维化组织的切除部位观察到角膜白斑的混浊。角膜切除术后两个月,在角膜中没有检测到进一步的变化,患者仅接受局部润滑剂治疗。
结论：据我们所知，这是猫特发性角膜脂肪增多症的首次报道，可作为猫角膜疾病的鉴别诊断。
方法：一只10岁的雌性欧洲家猫。
结果：评估一只猫的双侧白色角膜沉积。裂隙灯检查显示多个，定义明确，圆形,基质,与广泛性浅表角膜血管形成相关的不同大小的奶油色沉积物。血脂正常,没有前往热带地区或眼外伤的病史。在12小时内局部使用倍他米松/庆大霉素0.1%混悬液,一周后没有导致临床外观的任何改善。初始治疗后的体层摄影术显示密集，在两个角膜的前和中基质中具有后阴影的高反射沉积物。在12小时内开出为期四周的伊曲康唑0.01％眼霜疗程，无改善。初检四个月后,进行了诊断性浅表角膜切除术和羊膜植入术.组织病理学分析显示膜结合的液泡，泡沫巨噬细胞浸润，提示诊断为原发性脂肪增多。手术后的时期并不明显，十天后,患者被重新检查。在具有轻度纤维化组织的切除部位观察到角膜白斑的混浊。角膜切除术后两个月,在角膜中没有检测到进一步的变化,患者仅接受局部润滑剂治疗。
结论：据我们所知，这是猫特发性角膜脂肪增多症的首次报道，可作为猫角膜疾病的鉴别诊断。
