Abstract：
Chronic pain is challenging to treat due to the limited therapeutic options and adverse side-effects of therapies. Astrocytes are the most abundant glial cells in the central nervous system and play important roles in different pathological conditions, including chronic pain. Astrocytes regulate nociceptive synaptic transmission and network function via neuron-glia and glia-glia interactions to exaggerate pain signals under chronic pain conditions. It is also becoming clear that astrocytes play active roles in brain regions important for the emotional and memory-related aspects of chronic pain. Therefore, this review presents our current understanding of the roles of astrocytes in chronic pain, how they regulate nociceptive responses, and their cellular and molecular mechanisms of action.
摘要：
由于有限的治疗选择和治疗的不良副作用，慢性疼痛的治疗具有挑战性。星形胶质细胞是中枢神经系统中最丰富的神经胶质细胞,在不同病理条件下发挥重要作用,包括慢性疼痛。星形胶质细胞通过神经元-神经胶质和神经胶质相互作用调节伤害性突触传递和网络功能，以在慢性疼痛条件下夸大疼痛信号。也越来越清楚的是，星形胶质细胞在对慢性疼痛的情绪和记忆相关方面很重要的大脑区域中发挥着积极的作用。因此,这篇综述介绍了我们目前对星形胶质细胞在慢性疼痛中的作用的理解，它们如何调节伤害性反应，以及它们的细胞和分子作用机制。
