Abstract：
The aim is to evaluate the diagnostic value of Activin A levels in serum and pleural fluid on Parapneumonic Pleural Effusion (PPE).
The authors collected serum and pleural fluid from 86 PPE and 37 Non-PPE (NPPE) patients. Including Activin A, levels of biomarkers such as Lactate Dehydrogenase (LDH), Procalcitonin (PCT), and C-Reactive Protein (CRP) were measured. All factors were calculated for association with days after admission. The diagnostic potential of biomarkers on PPE was considered by Receiver Operating Characteristic (ROC) curve analysis.
Levels of Activin A in serum and pleural fluid of PPE patients were significantly higher than those of the NPPE patients. Moreover, concentrations of Activin A in pleural fluid showed a more obvious relevant days after admission. ROC curve analysis found that Activin A in pleural fluid had AUCs of 0.899 with 93% sensitivity and 84% specificity for PPE diagnosis.
Activin A in pleural fluid correlated with disease severity could act to diagnose PPE.
The authors collected serum and pleural fluid from 86 PPE and 37 Non-PPE (NPPE) patients. Including Activin A, levels of biomarkers such as Lactate Dehydrogenase (LDH), Procalcitonin (PCT), and C-Reactive Protein (CRP) were measured. All factors were calculated for association with days after admission. The diagnostic potential of biomarkers on PPE was considered by Receiver Operating Characteristic (ROC) curve analysis.
Levels of Activin A in serum and pleural fluid of PPE patients were significantly higher than those of the NPPE patients. Moreover, concentrations of Activin A in pleural fluid showed a more obvious relevant days after admission. ROC curve analysis found that Activin A in pleural fluid had AUCs of 0.899 with 93% sensitivity and 84% specificity for PPE diagnosis.
Activin A in pleural fluid correlated with disease severity could act to diagnose PPE.
摘要：
目的是评估血清和胸腔液中激活素A水平对肺炎旁胸腔积液（PPE）的诊断价值。
作者收集了86名PPE和37名非PPE（NPPE）患者的血清和胸膜液。包括激活素A,生物标志物的水平，如乳酸脱氢酶（LDH），降钙素原(PCT),测定C反应蛋白(CRP)。计算所有因素与入院后天数的相关性。通过受试者工作特征（ROC）曲线分析考虑了生物标志物对PPE的诊断潜力。
PPE患者血清和胸水中的激活素A水平明显高于NPPE患者。此外，胸膜液中激活素A的浓度在入院后的天数表现出更明显的相关性。ROC曲线分析发现，胸膜液中激活素A的AUC为0.899，诊断PPE的敏感性为93％，特异性为84％。
胸膜液中激活素A与疾病严重程度相关，可用于诊断PPE。
作者收集了86名PPE和37名非PPE（NPPE）患者的血清和胸膜液。包括激活素A,生物标志物的水平，如乳酸脱氢酶（LDH），降钙素原(PCT),测定C反应蛋白(CRP)。计算所有因素与入院后天数的相关性。通过受试者工作特征（ROC）曲线分析考虑了生物标志物对PPE的诊断潜力。
PPE患者血清和胸水中的激活素A水平明显高于NPPE患者。此外，胸膜液中激活素A的浓度在入院后的天数表现出更明显的相关性。ROC曲线分析发现，胸膜液中激活素A的AUC为0.899，诊断PPE的敏感性为93％，特异性为84％。
胸膜液中激活素A与疾病严重程度相关，可用于诊断PPE。
