UNASSIGNED: A retrospective, interventional case series was assembled from three ADNIV patients.
UNASSIGNED: The three ADNIV cases harbored de novo CAPN5 mutations (p.Arg289Trp and p.Leu73Val). The ages of onset ranged from 11 months to 2 years. All the cases presented with vitreous opacity and subretinal inflammatory exudations. During the postoperative follow-up, all the patients manifested with exaggerated postoperative inflammatory responses. An intravitreal Ozurdex injection could not effectively control ocular inflammation in ADNIV. Laser spots after panretinal photocoagulation were partly visible.
UNASSIGNED: Two de novo CAPN5 mutations (p.Leu73Val and p.Arg289Trp) could cause early-onset ADNIV. Panretinal photocoagulation during vitrectomy and an intravitreal Ozurdex injection could not significantly stop the progression of subretinal exudations and ocular inflammation in early-onset ADNIV patients.
■回顾,介入病例系列由3例ADNIV患者组成。
■三例ADNIV病例均具有从头CAPN5突变(p。Arg289Trp和p.Leu73Val)。发病年龄为11个月至2岁。所有病例均表现为玻璃体混浊和视网膜下炎症渗出。术后随访期间,所有患者均表现为术后炎症反应过度。玻璃体内注射Ozurdex不能有效控制ADNIV中的眼部炎症。全视网膜光凝后的激光斑点部分可见。
■两个从头CAPN5突变(p。Leu73Val和p.Arg289Trp)可引起早发性ADNIV。玻璃体切除术期间的全视网膜光凝和玻璃体内注射Ozurdex不能显着阻止早发性ADNIV患者视网膜下渗出和眼部炎症的进展。