Abstract：
Colorectal cancer (CRC) is one of the leading malignancies that causes death worldwide. Cancer vaccines and oncolytic immunotherapy bring new hope for patients with advanced CRC. The capability of vaccinia virus (VV) in carrying foreign genes as antigens or immunostimulatory factors has been demonstrated in animal models. VV of Wyeth, Western Reserve, Lister, Tian Tan, and Copenhagen strains have been engineered for the induction of antitumor response in multiple cancers. This paper summarized the preclinical and clinical application and development of VV serving as cancer vaccines and oncolytic vectors in CRC treatment. Additionally, the remaining challenges and future direction are also discussed.
摘要：
结直肠癌(CRC)是世界范围内导致死亡的主要恶性肿瘤之一。肿瘤疫苗和溶瘤免疫治疗为晚期CRC患者带来新的希望。牛痘病毒（VV）携带外源基因作为抗原或免疫刺激因子的能力已在动物模型中得到证实。惠氏的VV,西部保护区,李斯特,田谭,和哥本哈根菌株已被设计用于在多种癌症中诱导抗肿瘤反应。本文综述了VV作为癌症疫苗和溶瘤载体在CRC治疗中的临床前和临床应用及发展。此外,还讨论了剩余的挑战和未来的方向。
