Abstract：
In contrast to Alzheimer\'s disease (AD)-related pathology, the influence of comorbid limbic-predominant age-related TDP-43 encephalopathy neuropathological change (LATE-NC) or argyrophilic grains (AG) on structural imaging in Lewy body disease (LBD) has seldom been evaluated.
This study aimed to investigate whether non-AD limbic comorbidities, including LATE-NC and AG, cause cortical atrophy in LBD.
Seventeen patients with pathologically confirmed LBD with lower Braak neurofibrillary tangle stage (The mean age at antemortem magnetic resonance imaging of the mLBD patients was higher than that of the pLBD patients (84.3 ± 3.9 vs. 76.5 ± 10.5; p = .046). Irrespective of the presence or absence of comorbid LATE-NC or AG, all patients were clinically diagnosed with probable dementia with Lewy bodies or Parkinson\'s disease with dementia, respectively. Compared to the pLBD group, the mLBD group showed more conspicuous cortical atrophy of the bilateral hippocampus, amygdala, and temporal pole.
Non-AD limbic comorbidities, including LATE-NC and AG, are associated with limbic and temporal atrophy in older patients with LBD. Therefore, the possibility of non-AD limbic comorbidities should be considered in the diagnosis of elderly patients with dementia with clinical symptoms of LBD and medial temporal atrophy.
This study aimed to investigate whether non-AD limbic comorbidities, including LATE-NC and AG, cause cortical atrophy in LBD.
Seventeen patients with pathologically confirmed LBD with lower Braak neurofibrillary tangle stage (
Non-AD limbic comorbidities, including LATE-NC and AG, are associated with limbic and temporal atrophy in older patients with LBD. Therefore, the possibility of non-AD limbic comorbidities should be considered in the diagnosis of elderly patients with dementia with clinical symptoms of LBD and medial temporal atrophy.
摘要：
与阿尔茨海默病（AD）相关的病理学相反，很少评估以边缘为主导的年龄相关性TDP-43脑病神经病理学改变(LATE-NC)或嗜银颗粒(AG)对路易体病(LBD)结构成像的影响.
本研究旨在探讨非AD边缘合并症，包括LATE-NC和AG，引起LBD皮质萎缩。
包括17例经病理证实的具有较低Braak神经原纤维缠结期（mLBD患者的死前磁共振成像平均年龄高于pLBD患者（84.3±3.9vs.76.5±10.5；p=.046）。无论是否存在LATE-NC或AG合并症，所有患者临床诊断为路易体痴呆或帕金森病痴呆，分别。与pLBD组相比，mLBD组表现出更明显的双侧海马皮质萎缩，杏仁核,和时间极点。
非AD边缘合并症，包括LATE-NC和AG，与老年LBD患者的边缘和颞部萎缩有关。因此,在诊断具有LBD和颞叶内侧萎缩的临床症状的老年痴呆患者时，应考虑非AD边缘合并症的可能性。
本研究旨在探讨非AD边缘合并症，包括LATE-NC和AG，引起LBD皮质萎缩。
包括17例经病理证实的具有较低Braak神经原纤维缠结期（
非AD边缘合并症，包括LATE-NC和AG，与老年LBD患者的边缘和颞部萎缩有关。因此,在诊断具有LBD和颞叶内侧萎缩的临床症状的老年痴呆患者时，应考虑非AD边缘合并症的可能性。
