Abstract：
OBJECTIVE: The purpose of this study is to study laboratory indicators for the identification of hand, foot, and mouth disease (HFMD) severity.
METHODS: We searched PubMed, Embase, and the Web of Science for literature that was published before May 2022. The main results are presented as forest plots. Subgroup analyses, sensitivity analyses, and publication bias were also performed.
RESULTS: Our study indicated that white blood cells (WBC) (95%CI: 0.205-0.778), blood glucose (95%CI: 0.505-0.778), lymphocytes (95%CI: 0.072-0.239), creatinine (95%CI: 0.024-0.228), interleukin (IL)-2 (95%CI: 0.192-1.642), IL-6 (95%CI: 0.289-0.776), IL-8 (95%CI: 0.499-0.867), IL-10 (95%CI: 0.226-0.930), interferon-γ (IFN-γ) (95%CI: 0.193-2.584), tumor necrosis factor-α (TNF-α) (95%CI: 1.078-2.715), and creatine kinase MB isoenzyme (CK-MB) (95%CI: 0.571-1.459) were associated with an increased risk of HFMD severity, and the results of the sensitivity analysis of these indicators were stable and free of publication bias.
CONCLUSIONS: Our results suggest that various deleterious immune and metabolic changes can increase the risk of HFMD severity, which can provide a basis for predicting the prognosis and useful evidence for clinicians to manage patients efficiently.
METHODS: We searched PubMed, Embase, and the Web of Science for literature that was published before May 2022. The main results are presented as forest plots. Subgroup analyses, sensitivity analyses, and publication bias were also performed.
RESULTS: Our study indicated that white blood cells (WBC) (95%CI: 0.205-0.778), blood glucose (95%CI: 0.505-0.778), lymphocytes (95%CI: 0.072-0.239), creatinine (95%CI: 0.024-0.228), interleukin (IL)-2 (95%CI: 0.192-1.642), IL-6 (95%CI: 0.289-0.776), IL-8 (95%CI: 0.499-0.867), IL-10 (95%CI: 0.226-0.930), interferon-γ (IFN-γ) (95%CI: 0.193-2.584), tumor necrosis factor-α (TNF-α) (95%CI: 1.078-2.715), and creatine kinase MB isoenzyme (CK-MB) (95%CI: 0.571-1.459) were associated with an increased risk of HFMD severity, and the results of the sensitivity analysis of these indicators were stable and free of publication bias.
CONCLUSIONS: Our results suggest that various deleterious immune and metabolic changes can increase the risk of HFMD severity, which can provide a basis for predicting the prognosis and useful evidence for clinicians to manage patients efficiently.
摘要：
目的：本研究的目的是研究鉴定手的实验室指标，脚,和口蹄疫（HFMD）的严重程度。
方法：我们搜索了PubMed，Embase,以及2022年5月之前出版的WebofScience文献。主要结果以森林地块形式呈现。亚组分析，敏感性分析，并进行了发表偏倚.
结果：我们的研究表明，白细胞（WBC）（95CI：0.205-0.778），血糖（95CI：0.505-0.778），淋巴细胞（95CI：0.072-0.239），肌酐（95CI：0.024-0.228），白细胞介素（IL）-2（95CI：0.192-1.642），IL-6（95CI：0.289-0.776），IL-8（95CI：0.499-0.867），IL-10（95CI：0.226-0.930），干扰素-γ（IFN-γ）（95CI：0.193-2.584），肿瘤坏死因子-α（TNF-α）（95CI：1.078-2.715），肌酸激酶同工酶（CK-MB）（95CI：0.571-1.459）与手足口病严重程度的风险增加有关，这些指标的敏感性分析结果稳定，没有发表偏倚。
结论：我们的结果表明，各种有害的免疫和代谢变化可增加手足口病严重程度的风险，为预测预后提供依据,为临床医生有效管理患者提供有用的证据。
方法：我们搜索了PubMed，Embase,以及2022年5月之前出版的WebofScience文献。主要结果以森林地块形式呈现。亚组分析，敏感性分析，并进行了发表偏倚.
结果：我们的研究表明，白细胞（WBC）（95CI：0.205-0.778），血糖（95CI：0.505-0.778），淋巴细胞（95CI：0.072-0.239），肌酐（95CI：0.024-0.228），白细胞介素（IL）-2（95CI：0.192-1.642），IL-6（95CI：0.289-0.776），IL-8（95CI：0.499-0.867），IL-10（95CI：0.226-0.930），干扰素-γ（IFN-γ）（95CI：0.193-2.584），肿瘤坏死因子-α（TNF-α）（95CI：1.078-2.715），肌酸激酶同工酶（CK-MB）（95CI：0.571-1.459）与手足口病严重程度的风险增加有关，这些指标的敏感性分析结果稳定，没有发表偏倚。
结论：我们的结果表明，各种有害的免疫和代谢变化可增加手足口病严重程度的风险，为预测预后提供依据,为临床医生有效管理患者提供有用的证据。
