Abstract：
Previous studies have shown that a resistant dextrin soluble fibre has prebiotic properties with related health benefits on blood glucose management and satiety. Our aim was to demonstrate the effects of continuous administration of resistant dextrin on intestinal gas production, digestive sensations, and gut microbiota metabolism and composition. Healthy subjects (n = 20) were given resistant dextrin (14 g/d NUTRIOSE®, Roquette Frères, Lestrem, France) for four weeks. Outcomes were measured before, at the beginning, end, and two weeks after administration: anal evacuations of gas during daytime; digestive perception, girth, and gas production in response to a standard meal; sensory and digestive responses to a comfort meal; volume of colonic biomass by magnetic resonance; taxonomy and metabolic functions of fecal microbiota by shotgun sequencing; metabolomics in urine. Dextrin administration produced an initial increase in intestinal gas production and gas-related sensations, followed by a subsequent decrease, which magnified after discontinuation. Dextrin enlarged the volume of colonic biomass, inducing changes in microbial metabolism and composition with an increase in short chain fatty acids-producing species and modulation of bile acids and biotin metabolism. These data indicate that consumption of a soluble fibre induces an adaptative response of gut microbiota towards fermentative pathways with lower gas production.
摘要：
先前的研究表明，抗性糊精可溶性纤维具有益生元特性，对血糖管理和饱腹感具有相关的健康益处。我们的目的是证明持续施用抗性糊精对肠道气体产生的影响，消化的感觉，和肠道菌群代谢和组成。健康受试者(n=20)给予抗性糊精(14g/dNUTRIOSE®，RoquetteFrères,Lestrem,法国）四个星期。结果是以前测量过的，一开始,结束,给药后两周：白天肛门排空气体；消化感知，腰围,和响应标准膳食的气体产生;对舒适膳食的感觉和消化反应;磁共振结肠生物量的体积;通过鸟枪测序的粪便微生物群的分类学和代谢功能;尿液中的代谢组学。右旋糖酐给药产生了肠道气体产生和气体相关感觉的初始增加，随后下降，停药后放大了。糊精增加了结肠生物量的体积，随着产生短链脂肪酸的种类的增加以及胆汁酸和生物素代谢的调节，诱导微生物代谢和组成的变化。这些数据表明，可溶性纤维的消耗会诱导肠道微生物群对发酵途径的适应性反应，而气体产量较低。
