What to do about hepatocellular carcinoma: Recommendations for health authorities from the International Liver Cancer Association.

如何处理肝细胞癌 ： 国际肝癌协会对卫生当局的建议。

• 影响指数: 9.917
• 发表时间: Dec 2022
• 来源期刊: JHEP Rep
• DOI: 10.1016/j.jhepr.2022.100578
• PMID: 36352896
• 文章类型: Journal Article
• 作者列表: Allaire M,Bruix J,Korenjak M,Manes S,Maravic Z,Reeves H,Salem R,Sangro B,Sherman M

关键词: AASLD, American Association for the Study of Liver Disease; AFP, alpha-fetoprotein; ALT, alanine aminotransferase; APRI, aspartate aminotransferase-to-platelet ratio index; Alcohol consumption; BCLC, Barcelona clinic liver cancer; DCP, des-gammacarboxy prothrombin; DEB-TACE, TACE with drug-eluting beads; EASL, European Association for the study of the Liver; EBRT, external beam radiation therapy; ELF, enhanced liver fibrosis; GGT, gamma-glutamyltransferase; HCC, hepatocellular carcinoma; Hepatocellular carcinoma; Hepatocellular carcinoma surveillance; Hepatocellular carcinoma treatment; Li-RADS, Liver Imaging Reporting and Data System; NAFLD, non-alcoholic fatty liver disease; Obesity; RFA, radiofrequency ablation; TACE, transarterial chemoembolisation; TARE, transarterial radioembolisation; TKI, tyrosine kinase inhibitor; Viral hepatitis; cTACE, conventional TACE

Abstract

Hepatocellular carcinoma (HCC) is a major public health problem worldwide for which the incidence and mortality are similar, pointing to the lack of effective treatment options. Knowing the different issues involved in the management of HCC, from risk factors to screening and management, is essential to improve the prognosis and quality of life of affected individuals. This document summarises the current state of knowledge and the unmet needs for all the different stakeholders in the care of liver cancer, meaning patients, relatives, physicians, regulatory agencies and health authorities so that optimal care can be delivered to patients. The document was commissioned by the International Liver Cancer Association and was reviewed by senior members, including two ex-presidents of the Association. This document lays out the recommended approaches to the societal management of HCC based on the economic status of a given region.

摘要

肝细胞癌（HCC）是全球范围内的主要公共卫生问题，其发病率和死亡率相似。指出缺乏有效的治疗选择。了解HCC管理中涉及的不同问题，从风险因素到筛查和管理，对于改善受影响个体的预后和生活质量至关重要。本文件总结了目前的知识状态和未满足的需求，所有不同的利益相关者在肝癌的护理，意味着患者，亲戚,医师,监管机构和卫生当局，以便为患者提供最佳护理。这份文件是由国际肝癌协会委托,并由资深会员进行评审,包括该协会的两位前主席。本文件根据给定地区的经济状况，提出了HCC社会管理的推荐方法。