PDF(Pubmed)
Abstract：
UNASSIGNED: Retinopathy of prematurity (ROP) is increasing in incidence in developing nations, including Egypt. Secondary prevention requires timely detection through the development of regional screening guidelines, which should be preceded by large-scale studies to characterize the population at risk.
UNASSIGNED: A prospective, multicentric exploratory study that included five large tertiary institutions in an urban Egyptian setting. All infants born with gestational age (GA) < 37 weeks and/or birth weight (BW) ≤ 2000 grams were screened. More mature and heavier infants with unstable clinical course were also included. The primary outcome measure was the rate of ROP and high-risk disease occurrence in relation to underlying risk factors.
UNASSIGNED: Of the 768 eyes (384 screened infants), 347 eyes (45.2%) had stage 1 or higher disease, and 43 eyes (5.6%) had high-risk disease. Eyes with stage 1 or higher ROP and treatment-requiring ROP had a mean (± SD) GA of 33.4 (± 2.6) weeks and 32.8 (± 3.2) weeks, and BW of 1842.3 (± 570.1) grams and 1747.6 ± (676.2) grams, respectively. Treatment-requiring eyes belonged to infants that had significantly lower GA and significantly higher prevalence of co-morbidities than non-treatment-requiring eyes.
UNASSIGNED: The incidence of ROP and high-risk disease in an urban Egyptian setting are similar to those in comparable settings elsewhere and locally. This exploratory study supports tailoring local screening criteria for ROP, and may aid the future development of national guidelines.
UNASSIGNED: A prospective, multicentric exploratory study that included five large tertiary institutions in an urban Egyptian setting. All infants born with gestational age (GA) < 37 weeks and/or birth weight (BW) ≤ 2000 grams were screened. More mature and heavier infants with unstable clinical course were also included. The primary outcome measure was the rate of ROP and high-risk disease occurrence in relation to underlying risk factors.
UNASSIGNED: Of the 768 eyes (384 screened infants), 347 eyes (45.2%) had stage 1 or higher disease, and 43 eyes (5.6%) had high-risk disease. Eyes with stage 1 or higher ROP and treatment-requiring ROP had a mean (± SD) GA of 33.4 (± 2.6) weeks and 32.8 (± 3.2) weeks, and BW of 1842.3 (± 570.1) grams and 1747.6 ± (676.2) grams, respectively. Treatment-requiring eyes belonged to infants that had significantly lower GA and significantly higher prevalence of co-morbidities than non-treatment-requiring eyes.
UNASSIGNED: The incidence of ROP and high-risk disease in an urban Egyptian setting are similar to those in comparable settings elsewhere and locally. This exploratory study supports tailoring local screening criteria for ROP, and may aid the future development of national guidelines.
摘要：
未经证实：在发展中国家，早产儿视网膜病变（ROP）的发病率正在增加，包括埃及。二级预防需要通过制定区域筛查指南来及时发现,在此之前，应该进行大规模研究，以描述处于危险中的人群。
未经批准：预期，多中心探索性研究，包括埃及城市环境中的五所大型高等教育机构。对所有胎龄(GA)<37周和/或出生体重(BW)≤2000克的婴儿进行筛查。还包括临床病程不稳定的更成熟和更重的婴儿。主要结果指标是ROP率和高危疾病发生率与潜在危险因素的关系。
未经评估：在768只眼睛（384只经过筛查的婴儿）中，347眼（45.2%）有1期或以上疾病，43眼(5.6%)有高危疾病。具有1期或更高ROP和需要治疗的ROP的眼睛平均（±SD）GA为33.4（±2.6）周和32.8（±3.2）周，BW为1842.3(±570.1)克和1747.6±(676.2)克，分别。需要治疗的眼睛属于与不需要治疗的眼睛相比具有显著更低的GA和显著更高的合并症患病率的婴儿。
UNASSIGNED：在埃及城市环境中，ROP和高风险疾病的发病率与其他地方和当地的可比环境中的发病率相似。这项探索性研究支持为ROP定制当地筛查标准，并可能有助于国家指导方针的未来发展。
未经批准：预期，多中心探索性研究，包括埃及城市环境中的五所大型高等教育机构。对所有胎龄(GA)<37周和/或出生体重(BW)≤2000克的婴儿进行筛查。还包括临床病程不稳定的更成熟和更重的婴儿。主要结果指标是ROP率和高危疾病发生率与潜在危险因素的关系。
未经评估：在768只眼睛（384只经过筛查的婴儿）中，347眼（45.2%）有1期或以上疾病，43眼(5.6%)有高危疾病。具有1期或更高ROP和需要治疗的ROP的眼睛平均（±SD）GA为33.4（±2.6）周和32.8（±3.2）周，BW为1842.3(±570.1)克和1747.6±(676.2)克，分别。需要治疗的眼睛属于与不需要治疗的眼睛相比具有显著更低的GA和显著更高的合并症患病率的婴儿。
UNASSIGNED：在埃及城市环境中，ROP和高风险疾病的发病率与其他地方和当地的可比环境中的发病率相似。这项探索性研究支持为ROP定制当地筛查标准，并可能有助于国家指导方针的未来发展。
