PDF(Pubmed)
Abstract：
Internationally, potential effects of national SARS-CoV-2-related lockdowns on stillbirth rates have been reported, but data for Germany, including risk factors for fetal pregnancy outcome, are lacking. The aim of this study is to compare the stillbirth rates during the two first lockdown periods in 2020 with previous years from 2010 to 2019 in a large Bavarian cohort.
This study is a secondary analysis of the Bavarian perinatal data from 2010 to 2020, including 349,245 births. Univariate and multivariable regression analyses were performed to investigate the effect of two Bavarian lockdowns on the stillbirth rate in 2020 compared to the corresponding periods from 2010 to 2019.
During the first lockdown, the stillbirth rate was significantly higher compared to the reference period (4.04 vs. 3.03 stillbirths per 1000 births; P = 0.03). After adjustment for seasonal and long-term trends, this effect can no longer be observed (P = 0.2). During the second lockdown, the stillbirth rate did not differ in univariate (3.46 vs. 2.93 stillbirths per 1000 births; P = 0.22) as well as in multivariable analyses (P = 0.68), compared to the years 2010 to 2019.
After adjustment for known long-term effects, in this study we did not find evidence that the two Bavarian lockdowns had an effect on the rate of stillbirths.
This study is a secondary analysis of the Bavarian perinatal data from 2010 to 2020, including 349,245 births. Univariate and multivariable regression analyses were performed to investigate the effect of two Bavarian lockdowns on the stillbirth rate in 2020 compared to the corresponding periods from 2010 to 2019.
During the first lockdown, the stillbirth rate was significantly higher compared to the reference period (4.04 vs. 3.03 stillbirths per 1000 births; P = 0.03). After adjustment for seasonal and long-term trends, this effect can no longer be observed (P = 0.2). During the second lockdown, the stillbirth rate did not differ in univariate (3.46 vs. 2.93 stillbirths per 1000 births; P = 0.22) as well as in multivariable analyses (P = 0.68), compared to the years 2010 to 2019.
After adjustment for known long-term effects, in this study we did not find evidence that the two Bavarian lockdowns had an effect on the rate of stillbirths.
摘要：
背景：国际上，据报道，国家SARS-CoV-2相关封锁对死胎率的潜在影响，但是德国的数据，包括胎儿妊娠结局的危险因素，缺乏。这项研究的目的是在巴伐利亚大型队列中比较2020年两个首次封锁期与2010年至2019年的前几年的死胎率。
方法：本研究是对2010年至2020年巴伐利亚围产期数据的二次分析，其中包括349,245例分娩。进行了单变量和多变量回归分析，以调查与2010年至2019年相应时期相比，2020年两次巴伐利亚封锁对死胎率的影响。
结果：在第一次锁定期间，死胎率明显高于参考期(4.04vs.每1000名新生儿中有3.03例死胎；P=0.03）。经季节性和长期趋势调整后，不再观察到这种效应(P=0.2).在第二次封锁期间，死胎率在单变量中没有差异(3.46与每1000例新生儿中有2.93例死胎；P=0.22）以及多变量分析（P=0.68），与2010年至2019年相比。
结论：在调整已知的长期影响后，在这项研究中,我们没有发现巴伐利亚两次禁产对死产率有影响的证据.
方法：本研究是对2010年至2020年巴伐利亚围产期数据的二次分析，其中包括349,245例分娩。进行了单变量和多变量回归分析，以调查与2010年至2019年相应时期相比，2020年两次巴伐利亚封锁对死胎率的影响。
结果：在第一次锁定期间，死胎率明显高于参考期(4.04vs.每1000名新生儿中有3.03例死胎；P=0.03）。经季节性和长期趋势调整后，不再观察到这种效应(P=0.2).在第二次封锁期间，死胎率在单变量中没有差异(3.46与每1000例新生儿中有2.93例死胎；P=0.22）以及多变量分析（P=0.68），与2010年至2019年相比。
结论：在调整已知的长期影响后，在这项研究中,我们没有发现巴伐利亚两次禁产对死产率有影响的证据.
