Abstract：
The Toxoplasma gondii is an obligate intracellular protozoan parasite which significantly impact small ruminant productivity, international animal trade and transboundary movement of animal across the globe. The seroprevalence of T. gondii infection (toxoplasmosis) in sheep and goats is widely studied in many parts of the world and there is a lack of comprehensive information on prevalence estimates considering the global and regional perspectives. The aim of the study was to use systematic review and meta-analysis methods to estimate the global and regional pooled seroprevalence of T. gondii infection in sheep and goats, as well as factors that influence prevalence estimations. Relevant articles reporting the seroprevalence of toxoplasmosis in sheep and/goats were searched in five electronic databases, including PubMed, Web of Science, Scopus, Embase and ProQuest. After the publications were checked to verify they fit the inclusion criteria, a total of 225 articles were included in the systematic review and meta-analysis, reflecting data from 70 countries/regions. The pooled prevalence was estimated using a random effect meta-analysis model. Overall, the seroprevalence of T. gondii infection was 33.86% (95% CI: 30.47-37.25%) in sheep and 31.78% (95% CI: 28.99-34.58%) in goats, with significant variation in prevalence estimates across geographical locations (p < .001). Substantial heterogeneity (I2 > 75%) was observed in most pooled seroprevalence estimates. The T. gondii infection in global sheep and goat population showed uptrend over the period. This information would be useful for epidemiologist, health authorities and farmers in order to plan future T. gondii survey and infection management strategies both locally and internationally.
摘要：
弓形虫是一种专性的细胞内原生动物寄生虫，显著影响小反刍动物的生产力，国际动物贸易和动物在全球的越境转移。绵羊和山羊弓形虫感染（弓形虫病）的血清阳性率在世界许多地方都得到了广泛的研究，并且缺乏考虑全球和区域观点的患病率估计的全面信息。该研究的目的是使用系统评价和荟萃分析方法来估计绵羊和山羊弓形虫感染的全球和区域合并血清阳性率。以及影响患病率估计的因素。在五个电子数据库中检索了报告绵羊和/山羊弓形虫病血清阳性率的相关文章，包括PubMed,WebofScience,Scopus,Embase和ProQuest。在检查出版物以验证它们符合纳入标准后，共有225篇文章被纳入系统评价和荟萃分析，反映来自70个国家/地区的数据。使用随机效应荟萃分析模型估计合并患病率。总的来说,绵羊弓形虫感染的血清阳性率为33.86%(95%CI:30.47-37.25%)，山羊为31.78%(95%CI:28.99-34.58%)，不同地理位置的患病率估计值存在显著差异(p<.001)。在大多数合并的血清阳性率估计中观察到了显著的异质性(I2>75%)。在此期间，全球绵羊和山羊种群中的弓形虫感染呈上升趋势。这些信息对流行病学家很有用，卫生当局和农民，以便在本地和国际上规划未来的弓形虫调查和感染管理策略。
