Abstract:
Various artificial bone graft substitutes based on ceramics have been developed over the last 20 years. Among them, calcium-silicate-based ceramics, which are osteoconductive and can attach directly to biological organs, have received great attention for bone tissue engineering applications. However, the degradation rate of calcium-silicate and bone formation is often out of balance, resulting in stress shielding (osteopenia). A new strategy to improve the drawbacks of these ceramics is incorporating trace elements such as Zn, Mg, and Zr into their lattice structures, enhancing their physical and biological properties. Recently, baghdadite (Ca3ZrSi2O9) ceramic, one of the most appealing calcium-silicate-based ceramics, has demonstrated high bioactivity, biocompatibility, biodegradability, and cell interaction. Because of its physical, mechanical, and biological properties and ability to be shaped using various fabrication techniques, baghdadite has found high potential in various biomedical applications such as coatings, fillers, cement, scaffolds, and drug delivery systems. Undoubtedly, there is a high potential for this newly developed ceramic to contribute significantly to therapies to provide a tremendous clinical outcome. This review paper aims to summarize and discuss the most relevant studies performed on baghdadite-based ceramics and composites by focusing on their behavior in vivo and in vitro.
摘要:
在过去的20年中,已经开发了各种基于陶瓷的人造骨移植替代品。其中,硅酸钙基陶瓷,它们具有骨传导性,可以直接附着在生物器官上,骨组织工程应用受到了极大的关注。然而,硅酸钙的降解速率和骨形成往往失去平衡,导致应力屏蔽(骨质减少)。改善这些陶瓷缺点的新策略是掺入微量元素,如锌,Mg,和Zr进入它们的晶格结构,增强其物理和生物学特性。最近,Baghdadite(Ca3ZrSi2O9)陶瓷,最吸引人的硅酸钙基陶瓷之一,表现出很高的生物活性,生物相容性,生物降解性,和细胞相互作用。因为它的物理,机械,以及使用各种制造技术成形的生物学特性和能力,Baghdadite在各种生物医学应用中具有很高的潜力,例如涂料,填料,水泥,脚手架,和药物输送系统。毫无疑问,这种新开发的陶瓷具有很高的潜力,可以显着促进治疗,从而提供巨大的临床结果。这篇综述论文旨在通过关注Baghdadite基陶瓷和复合材料在体内和体外的行为来总结和讨论最相关的研究。