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Abstract：
Cryoglobulinaemia can manifest as fatigue, purpura, and joint pain, and can involve the kidneys and peripheral nervous system. Type II and mixed cryoglobulinemia cases are usually associated with hepatitis C virus infection and autoimmune diseases, and most cases reported outside China have been related to hepatitis C virus. The pathological manifestation of cryoglobulinaemia glomerulonephritis is always membranous proliferative glomerulonephritis or membranous nephropathy; other pathological types are rare. This current case report describes a female patient with hepatitis B virus (HBV)-associated cryoglobulinaemic glomerulonephritis. The patient had hepatitis B complicated with purpura, abnormal urinalysis and renal function. She was positive for rheumatoid factor and had decreased complement, and her blood cryoglobulin level was positive. The pathological findings were consistent with late-stage capillary proliferative glomerulonephritis, which improved after steroid, immunosuppressant and anti-HBV treatment.
摘要：
冷球蛋白血症可以表现为疲劳，紫癜,关节疼痛,并可累及肾脏和周围神经系统。II型和混合型冷球蛋白血症病例通常与丙型肝炎病毒感染和自身免疫性疾病有关，中国以外报告的大多数病例与丙型肝炎病毒有关。冷球蛋白血症肾小球肾炎的病理表现常为膜增殖性肾小球肾炎或膜性肾病，其他病理类型少见。此当前病例报告描述了一名患有乙型肝炎病毒（HBV）相关冷球蛋白血症性肾小球肾炎的女性患者。病人有乙型肝炎合并紫癜,尿液分析和肾功能异常。她的类风湿因子呈阳性，补体减少，她的血冷球蛋白水平呈阳性.病理结果符合晚期毛细血管增生性肾小球肾炎,类固醇后有所改善，免疫抑制剂和抗HBV治疗。
