Abstract：
OBJECTIVE: Vitiligo is one of the most challenging dermatological diseases with little improvement promises. Various modalities of treatment both medical and surgical have been used in the treatment of vitiligo. Some proved to be effective, others with controversial results and the rest were effective less. The aim of the present study was to evaluate the additional effect of topical 5-fluorouracil after micro-needling to excimer light (308 nm) in treatment of non-segmental vitiligo.
METHODS: Fifty patients were included in the present study, only 33 patients continued the treatment for 6 months. Two patches were selected in every patient to be treated, one patch with micro-needling then application of 5 FU and excimer (Group A), and the other with excimer only (Group B).
RESULTS: The treatment with the combination of micro-needling then application of 5 FU and excimer showed significant earlier response versus excimer alone. Also, the percentage of re-pigmentation was higher in the patches treated with the combination especially in the face and trunk. The combination of 5 FU after micro-needling and Excimer is more suitable for localized and focal vitiligo.
CONCLUSIONS: Topical 5 FU after micro-needling is a promising, rapid, and cost-effective therapeutic strategy for treatment of non-segmental vitiligo It had limited side effects, and the best response was reported for lesions affecting face and trunk.
METHODS: Fifty patients were included in the present study, only 33 patients continued the treatment for 6 months. Two patches were selected in every patient to be treated, one patch with micro-needling then application of 5 FU and excimer (Group A), and the other with excimer only (Group B).
RESULTS: The treatment with the combination of micro-needling then application of 5 FU and excimer showed significant earlier response versus excimer alone. Also, the percentage of re-pigmentation was higher in the patches treated with the combination especially in the face and trunk. The combination of 5 FU after micro-needling and Excimer is more suitable for localized and focal vitiligo.
CONCLUSIONS: Topical 5 FU after micro-needling is a promising, rapid, and cost-effective therapeutic strategy for treatment of non-segmental vitiligo It had limited side effects, and the best response was reported for lesions affecting face and trunk.
摘要：
目的：白癜风是最具挑战性的皮肤病之一，几乎没有改善的希望。在白癜风的治疗中已经使用了各种医疗和手术治疗方式。有些被证明是有效的，其他有争议的结果，其余的效果较低。本研究的目的是评估局部5-氟尿嘧啶在微针刺准分子光（308nm）治疗非节段白癜风后的额外作用。
方法：本研究纳入50例患者，只有33例患者继续治疗6个月.在每位接受治疗的患者中选择了两个贴片，一个微针刺贴片，然后应用5FU和准分子（A组），另一个只使用准分子（B组）。
结果：与单独使用准分子相比，微针刺然后应用5FU和准分子的组合治疗显示出明显的早期反应。此外，在联合治疗的贴剂中,再色素沉着的百分比较高,尤其是在面部和躯干.微针后5FU和准分子的组合更适合局部和局灶性白癜风。
结论：微针刺后的局部5FU是有希望的，快速,和成本有效的治疗非节段白癜风的治疗策略，它有有限的副作用，并且报告了影响面部和躯干的病变的最佳反应。
方法：本研究纳入50例患者，
结果：与单独使用准分子相比，微针刺然后应用5FU和准分子的组合治疗显示出明显的早期反应。
结论：微针刺后的局部5FU是有希望的，
