METHODS: The Kihon Checklist Questionnaire (KCQ) was used to assess physical and psychiatric frailties and identify those at risk of requiring care among patients with newly diagnosed NTM-LD and BE. Additionally, the Hospital Anxiety and Depression Scale (HADS) scores and chronic inflammatory biomarkers of the alveolar region (surfactant protein [SP]-A, SP-D, and human cationic antibacterial protein [hCAP]/LL-37) were assessed and compared between NTM-LD and BE patients.
RESULTS: There were no significant differences in the background characteristics between the 33 NTM and 36 BE patients recruited. The KCQ revealed that the proportion of frail NTM patients at diagnosis was higher than that of frail BE patients (48.5% vs. 22.2%, p = 0.026). HADS scores were significantly higher in the NTM group than in the BE group (p < 0.01). Bronchoalveolar lavage fluid (BALF) hCAP/LL-37 and SP-D levels were significantly higher (p = 0.001), but serum hCAP/LL-37 levels were significantly lower in the NTM group than in the BE group (p = 0.023). However, there were no significant differences in the BALF and serum SP-D levels between the two groups.
CONCLUSIONS: The number of frail NTM patients at diagnosis was significantly higher than that of frail BE patients. Biomarker analysis suggested that the former had more localized lung inflammation than the latter.
BACKGROUND: This trial was prospectively registered in the Clinical Trials Registry (UMIN 000027652).
方法:使用Kihon检查表问卷(KCQ)评估新诊断为NTM-LD和BE的患者的身体和精神弱点,并确定有需要护理风险的患者。此外,医院焦虑和抑郁量表(HADS)评分和肺泡区域的慢性炎症生物标志物(表面活性蛋白[SP]-A,SP-D,和人阳离子抗菌蛋白[hCAP]/LL-37)在NTM-LD和BE患者之间进行了评估和比较。
结果:招募的33例NTM和36例BE患者的背景特征没有显着差异。KCQ显示,诊断时虚弱的NTM患者的比例高于虚弱的BE患者(48.5%vs.22.2%,p=0.026)。NTM组HADS评分明显高于BE组(p<0.01)。支气管肺泡灌洗液(BALF)hCAP/LL-37和SP-D水平显著增高(p=0.001),但NTM组血清hCAP/LL-37水平显著低于BE组(p=0.023)。然而,两组BALF和血清SP-D水平差异无统计学意义。
结论:诊断时虚弱的NTM患者的数量明显高于虚弱的BE患者。生物标志物分析表明,前者比后者具有更多的局部肺部炎症。
背景:该试验在临床试验注册中心(UMIN000027652)进行了前瞻性注册。