METHODS: Laboratory parameters and cirrhosis stage (CHILD and MELD) were recorded for the patient group included in the study. In addition, blood samples were taken from each case included in the study for LAL activity determination and LIPA gene analysis.
RESULTS: A statistically significant decrease in LAL activity was found in patients diagnosed with CC compared to the healthy group. LIPA gene analysis did not detect CESD in any patient group. Correlation analysis showed a positive correlation between LAL activity and white blood cell and platelet counts in both healthy volunteers and CC patient groups. In the univariate and multivariate logistic regression analysis of the parameters associated with the MELD of ≥10 in patients with CC, significant relationship was found between the MELD of ≥10 and the LAL activity.
CONCLUSIONS: In our study, LAL activity was significantly lower in CC patients than in the normal population. LAL activity level appears to be a parameter that can be used to assess the severity of cirrhosis.
方法:记录纳入研究的患者组的实验室参数和肝硬化分期(CHILD和MELD)。此外,从研究中包括的每个病例中采集血液样本,用于LAL活性测定和LIPA基因分析。
结果:与健康组相比,诊断为CC的患者的LAL活性有统计学意义的降低。LIPA基因分析在任何患者组中均未检测到CESD。相关分析表明,健康志愿者和CC患者组的LAL活性与白细胞和血小板计数呈正相关。在CC患者与MELD≥10相关的参数的单变量和多变量逻辑回归分析中,MELD≥10与LAL活性之间存在显著关系。
结论:在我们的研究中,CC患者的LAL活性明显低于正常人群。LAL活性水平似乎是可用于评估肝硬化严重程度的参数。