PDF(Sci-hub)
Abstract：
UNASSIGNED: Sporadic cerebral small vessel disease (SVD) and cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) share clinical and neuroimaging features and possibly vascular dysfunction(s). However few studies have included both conditions, assessed more than one vascular dysfunction simultaneously, or included more than one centre. The INVESTIGATE-SVDs study will assess several cerebrovascular dysfunctions with MRI in participants with sporadic SVD or CADASIL at three European centres.
UNASSIGNED: We will recruit participants with sporadic SVDs (ischaemic stroke or vascular cognitive impairment) and CADASIL in Edinburgh, Maastricht and Munich. We will perform detailed clinical and neuropsychological phenotyping of the participants, and neuroimaging including structural MRI, cerebrovascular reactivity MRI (CVR: using carbon dioxide challenge), phase contrast MRI (arterial, venous and CSF flow and pulsatility), dynamic contrast-enhanced MRI (blood brain barrier (BBB) leakage) and multishell diffusion imaging. Participants will measure their blood pressure (BP) and its variability over seven days using a telemetric device.
UNASSIGNED: INVESTIGATE-SVDs will assess the relationships of BBB integrity, CVR, pulsatility and CSF flow in sporadic SVD and CADASIL using a multisite, multimodal MRI protocol. We aim to establish associations between these measures of vascular function, risk factors particularly BP and its variability, and brain parenchymal lesions in these two SVD phenotypes. Additionally we will test feasibility of complex multisite MRI, provide reliable intermediary outcome measures and sample size estimates for future trials.
UNASSIGNED: We will recruit participants with sporadic SVDs (ischaemic stroke or vascular cognitive impairment) and CADASIL in Edinburgh, Maastricht and Munich. We will perform detailed clinical and neuropsychological phenotyping of the participants, and neuroimaging including structural MRI, cerebrovascular reactivity MRI (CVR: using carbon dioxide challenge), phase contrast MRI (arterial, venous and CSF flow and pulsatility), dynamic contrast-enhanced MRI (blood brain barrier (BBB) leakage) and multishell diffusion imaging. Participants will measure their blood pressure (BP) and its variability over seven days using a telemetric device.
UNASSIGNED: INVESTIGATE-SVDs will assess the relationships of BBB integrity, CVR, pulsatility and CSF flow in sporadic SVD and CADASIL using a multisite, multimodal MRI protocol. We aim to establish associations between these measures of vascular function, risk factors particularly BP and its variability, and brain parenchymal lesions in these two SVD phenotypes. Additionally we will test feasibility of complex multisite MRI, provide reliable intermediary outcome measures and sample size estimates for future trials.
摘要：
未经证实：散发性脑小血管病（SVD）和伴有皮质下梗死和白质脑病的常染色体显性遗传性脑动脉病（CADASIL）具有共同的临床和神经影像学特征，可能还有血管功能障碍。然而，很少有研究包括这两种条件，同时评估多个血管功能障碍，或包括多个中心。INVESTIGATE-SVDs研究将在三个欧洲中心的零星SVD或CADASIL参与者中通过MRI评估几种脑血管功能障碍。
UNASSIGNED：我们将在爱丁堡招募散发性SVD（缺血性中风或血管性认知障碍）和CADASIL的参与者，马斯特里赫特和慕尼黑。我们将对参与者进行详细的临床和神经心理学表型分析，和神经成像，包括结构MRI，脑血管反应性MRI（CVR：使用二氧化碳挑战），相位对比MRI(动脉，静脉和脑脊液流量和搏动)，动态对比增强MRI（血脑屏障（BBB）渗漏）和多壳扩散成像。参与者将使用遥测设备在七天内测量他们的血压（BP）及其变异性。
未经批准：调查-SVDs将评估BBB完整性的关系，CVR,使用多点的零星SVD和CADASIL中的搏动性和CSF流量，多模态MRI方案。我们的目标是建立这些血管功能指标之间的关联，风险因素，特别是BP及其变异性，和这两种SVD表型的脑实质病变。此外，我们将测试复杂的多部位MRI的可行性，为未来的试验提供可靠的中间结果测量和样本量估计.
UNASSIGNED：我们将在爱丁堡招募散发性SVD（缺血性中风或血管性认知障碍）和CADASIL的参与者，马斯特里赫特和慕尼黑。我们将对参与者进行详细的临床和神经心理学表型分析，和神经成像，包括结构MRI，脑血管反应性MRI（CVR：使用二氧化碳挑战），相位对比MRI(动脉，静脉和脑脊液流量和搏动)，动态对比增强MRI（血脑屏障（BBB）渗漏）和多壳扩散成像。参与者将使用遥测设备在七天内测量他们的血压（BP）及其变异性。
未经批准：调查-SVDs将评估BBB完整性的关系，CVR,使用多点的零星SVD和CADASIL中的搏动性和CSF流量，多模态MRI方案。我们的目标是建立这些血管功能指标之间的关联，风险因素，特别是BP及其变异性，和这两种SVD表型的脑实质病变。此外，我们将测试复杂的多部位MRI的可行性，为未来的试验提供可靠的中间结果测量和样本量估计.
