PDF(Pubmed)
Abstract：
The outbreak of the coronavirus (COVID-19) has heightened awareness of the importance of quick and easy testing. The convenience, speed, and timely results from point-of-care testing (POCT) in all vitro diagnostic devices has drawn the strong interest of researchers. However, there are still many challenges in the development of POCT devices, such as the pretreatment of samples, detection sensitivity, specificity, and so on. It is anticipated that the unique properties of nanomaterials, e.g., their magnetic, optical, thermal, and electrically conductive features, will address the deficiencies that currently exist in POCT devices. In this review, we mainly analyze the work processes of POCT devices, especially in nucleic acid detection, and summarize how novel nanomaterials used in various aspects of POCT products can improve performance, with the ultimate aims of offering new ideas for the application of nanomaterials and the overall development of POCT devices.
摘要：
冠状病毒(COVID-19)的爆发提高了人们对快速简便检测重要性的认识。方便,速度,在所有体外诊断设备中进行即时测试（POCT）的及时结果引起了研究人员的强烈兴趣。然而,POCT设备的发展仍然面临许多挑战，例如样品的预处理，检测灵敏度,特异性，等等。预计纳米材料的独特性质,例如，他们的磁性，光学，热,和导电特征，将解决目前POCT设备中存在的缺陷。在这次审查中,我们主要分析了POCT设备的工作过程，特别是在核酸检测中，并总结了在POCT产品各个方面使用的新型纳米材料如何提高性能，最终目的是为纳米材料的应用和POCT器件的整体发展提供新思路。
