Abstract：
The fabric-based wound dressings are hard to maintain a moist environment for wound healing while the hemostatic property and gas permeability of some hydrogel-based wound dressings are not ideal. This study first put forward a strategy of checkerboard-pattern wound dressing: 1) preparing the base fabric with hemostatic property, 2) printing multifunctional hydrogels onto one side of the base fabric to form checkerboard patterns, 3) modifying the other side of the base fabric to be hydrophobic. In this manner, the composite dressing not only maintained the advantages of hydrogels, but also inherited good mechanical property, hemostatic property, and gas permeability from the base fabric. Here, the cotton fabric was carboxymethylated to be MCF. To obtain multifunctional hydrogel, sodium carboxymethylcellulose was oxidated to introduce aldehyde groups to form Schiff base with amino groups in gelatin, besides, dopamine and Ag nanoparticles were introduced to endow the hydrogel with antioxidant property and antibacterial activity. The multifunctional hydrogel was printed onto one side of MCF, subsequently, the deposition of paraffin made the other side of this dressing become hydrophobic. The good performance of the obtained dressing in hemostatic process and wound healing demonstrated its potential in the field of wound treatment.
摘要：
基于织物的伤口敷料难以维持用于伤口愈合的潮湿环境,而一些基于水凝胶的伤口敷料的止血性质和气体渗透性不理想。本研究首先提出了一种棋盘形伤口敷料的策略:1)制备具有止血性能的基布,2)将多功能水凝胶印刷到基布的一面上，形成棋盘图案，3)将基础织物的另一侧改性为疏水的。以这种方式,复合敷料不仅保持了水凝胶的优点，而且还继承了良好的机械性能，止血性能，和基础织物的透气性。这里,将棉织物羧甲基化为MCF。为了获得多功能水凝胶，羧甲基纤维素钠被氧化以引入醛基，从而在明胶中与氨基形成席夫碱，此外,引入多巴胺和Ag纳米颗粒赋予水凝胶抗氧化性能和抗菌活性。将多功能水凝胶印刷到MCF的一侧，随后,石蜡的沉积使得该敷料的另一侧变得疏水。所得敷料在止血过程和伤口愈合中的良好性能证明了其在伤口治疗领域的潜力。
