Abstract：
Ehlers-Danlos syndromes (EDS) are a group of disorders characterized by abnormal connective tissue affecting several organ systems. Patients with the hypermobile type of EDS (hEDS) commonly experience chronic pain which can present as musculoskeletal pain, fibromyalgia, neuropathic pain or abdominal pain. The effective management of chronic pain in hEDS patients is a challenge. This study reviews two cases of chronic pain in hEDS patients and the multimodal treatment regimen used along with peripheral nerve stimulation for shoulder and knee pains, never before reported in hEDS patients. Since hEDS associated chronic pain is multifactorial in origin, treatment requires a multidisciplinary approach which includes physical therapy, psychotherapy, pharmacotherapy and interventional pain procedures such as trigger point injections, peripheral nerve block, radiofrequency ablation and peripheral nerve stimulation.
Ehlers–Danlos Syndromes (EDS) are a group of disorders that affects the connective tissues that supports skin, muscles and organs. Patients with the hypermobile subtype of EDS (hEDS) often experience chronic pain of multiple locations including the muscles, joints, nerves, abdomen, head or generalized pain. Treating chronic pain in patients with hEDS is challenging. In this study, we review the treatment of chronic pain in two patients with hEDS using multiple therapies including the novel use of peripheral nerve stimulation in this patient population. Chronic pain in hEDS patients is caused by multiple different mechanisms and therefore, the treatment of this pain requires multiple different therapeutic interventions such as medications, physical therapy, psychotherapy and minimally invasive procedures such as peripheral nerve stimulation.
Ehlers–Danlos Syndromes (EDS) are a group of disorders that affects the connective tissues that supports skin, muscles and organs. Patients with the hypermobile subtype of EDS (hEDS) often experience chronic pain of multiple locations including the muscles, joints, nerves, abdomen, head or generalized pain. Treating chronic pain in patients with hEDS is challenging. In this study, we review the treatment of chronic pain in two patients with hEDS using multiple therapies including the novel use of peripheral nerve stimulation in this patient population. Chronic pain in hEDS patients is caused by multiple different mechanisms and therefore, the treatment of this pain requires multiple different therapeutic interventions such as medications, physical therapy, psychotherapy and minimally invasive procedures such as peripheral nerve stimulation.
摘要：
Ehlers-Danlos综合征（EDS）是一组以异常结缔组织影响多个器官系统为特征的疾病。高移动型EDS（hEDS）患者通常会经历慢性疼痛，可表现为肌肉骨骼疼痛，纤维肌痛,神经性疼痛或腹痛。hEDS患者慢性疼痛的有效管理是一个挑战。本研究回顾了2例hEDS患者的慢性疼痛，以及与周围神经刺激一起用于肩部和膝盖疼痛的多模式治疗方案。以前从未在hEDS患者中报告过。由于hEDS相关的慢性疼痛是多因素的，治疗需要多学科的方法，包括物理治疗，心理治疗,药物治疗和介入性疼痛程序，如触发点注射，周围神经阻滞,射频消融和周围神经刺激。
Ehlers-Danlos综合征（EDS）是一组影响支持皮肤的结缔组织的疾病，肌肉和器官具有高移动亚型EDS（hEDS）的患者通常会经历包括肌肉在内的多个位置的慢性疼痛，接头,神经,腹部，头部或全身疼痛。治疗hEDS患者的慢性疼痛具有挑战性。在这项研究中,我们回顾了2例hEDS患者使用多种疗法治疗慢性疼痛的情况,包括在该患者人群中使用周围神经刺激的新应用.hEDS患者的慢性疼痛是由多种不同的机制引起的，因此，这种疼痛的治疗需要多种不同的治疗干预措施，如药物治疗，物理治疗,心理治疗和微创手术，如周围神经刺激。
Ehlers-Danlos综合征（EDS）是一组影响支持皮肤的结缔组织的疾病，肌肉和器官具有高移动亚型EDS（hEDS）的患者通常会经历包括肌肉在内的多个位置的慢性疼痛，接头,神经,腹部，头部或全身疼痛。治疗hEDS患者的慢性疼痛具有挑战性。在这项研究中,我们回顾了2例hEDS患者使用多种疗法治疗慢性疼痛的情况,包括在该患者人群中使用周围神经刺激的新应用.hEDS患者的慢性疼痛是由多种不同的机制引起的，因此，这种疼痛的治疗需要多种不同的治疗干预措施，如药物治疗，物理治疗,心理治疗和微创手术，如周围神经刺激。
