Abstract：
BACKGROUND: An 80-year-old man presented with subacute mental status change, dizziness, and left-sided vision loss. Magnetic resonance imaging demonstrated a ring-enhancing right parietooccipital lesion.
METHODS: Biopsy and laboratory testing demonstrated an amoebic Balamuthia mandrillaris infection. Fewer than 200 cases of this infection have been recognized in the United States, and no standardized treatment regimen currently exists.
CONCLUSIONS: Rapid antimicrobial therapy with miltefosine, azithromycin, fluconazole, flucytosine, sulfadiazine, and albendazole was initiated. The pathophysiology, diagnosis, and management of this infection and the patient\'s course were reviewed. The importance of biopsy for pathologic and laboratory diagnosis and rapid treatment initiation with a multidisciplinary team was reinforced.
METHODS: Biopsy and laboratory testing demonstrated an amoebic Balamuthia mandrillaris infection. Fewer than 200 cases of this infection have been recognized in the United States, and no standardized treatment regimen currently exists.
CONCLUSIONS: Rapid antimicrobial therapy with miltefosine, azithromycin, fluconazole, flucytosine, sulfadiazine, and albendazole was initiated. The pathophysiology, diagnosis, and management of this infection and the patient\'s course were reviewed. The importance of biopsy for pathologic and laboratory diagnosis and rapid treatment initiation with a multidisciplinary team was reinforced.
摘要：
背景：一名80岁男性出现亚急性精神状态改变，头晕,左侧视力丧失。磁共振成像显示右顶枕骨环增强病变。
方法：活检和实验室检测显示变形虫感染。在美国，只有不到200例这种感染被确认，目前尚无标准化治疗方案。
结论：米替福辛快速抗菌治疗，阿奇霉素,氟康唑,氟胞嘧啶,磺胺嘧啶,并启动了阿苯达唑。病理生理学，诊断,并对该感染的管理和患者的病程进行了回顾。活检对于病理和实验室诊断以及多学科团队快速治疗的重要性得到了加强。
方法：活检和实验室检测显示变形虫感染。在美国，只有不到200例这种感染被确认，目前尚无标准化治疗方案。
结论：米替福辛快速抗菌治疗，阿奇霉素,氟康唑,氟胞嘧啶,磺胺嘧啶,并启动了阿苯达唑。病理生理学，诊断,并对该感染的管理和患者的病程进行了回顾。活检对于病理和实验室诊断以及多学科团队快速治疗的重要性得到了加强。
