Abstract：
Hypoxia is defined as a cellular stress condition caused by a decrease in oxygen below physiologically normal levels. Cells in the core of a rapidly growing solid tumor are faced with the challenge of inadequate supply of oxygen through the blood, owing to improper vasculature inside the tumor. This hypoxic microenvironment inside the tumor initiates a gene expression program that alters numerous signaling pathways, allowing the cancer cell to eventually evade adverse conditions and attain a more aggressive phenotype. A multitude of studies covering diverse aspects of gene regulation has tried to uncover the mechanisms involved in hypoxia-induced tumorigenesis. The role of epigenetics in executing widespread and dynamic changes in gene expression under hypoxia has been gaining an increasing amount of support in recent years. This chapter discusses, in detail, various epigenetic mechanisms driving the cellular response to hypoxia in cancer.
摘要：
低氧被定义为由氧降低到生理正常水平以下引起的细胞应激状态。快速生长的实体瘤的核心细胞面临着通过血液供应氧气不足的挑战，由于肿瘤内部的脉管系统不当。肿瘤内部的缺氧微环境启动了一个基因表达程序，改变了许多信号通路，允许癌细胞最终逃避不利条件并获得更具侵略性的表型。涵盖基因调控各个方面的大量研究试图揭示缺氧诱导的肿瘤发生的机制。近年来，表观遗传学在低氧条件下进行基因表达的广泛而动态的变化中的作用已获得越来越多的支持。本章讨论,在细节上,各种表观遗传机制驱动细胞对癌症缺氧的反应。
