PDF(Pubmed)
Abstract：
Gastric cancer (GC) is a worldwide health condition of major concern, with gastric carcinoma with signet ring cell features being increasingly reported. A 61-year-old woman was admitted to the Emergency department with back pain, gastrointestinal complaints, and weight loss. A lumbar and hip computed tomography (CT) was performed and revealed multiple suspicious secondary bone lesions. Laboratory test results reported anemia, thrombocytopenia, and elevated alkaline phosphatase. On thoracic-abdominal-pelvic CT, multiple bone lesions suggestive of metastases were visible on the vertebral spine, ribs, pelvic bones, and proximal femurs, but no identifiable primary or visceral lesions were described. Upper endoscopy identified a gastric adenocarcinoma, and both gastric and bone lesions, especially bone lesions, contained a relevant amount of signet ring cells. The patient was referred to the Medical Oncology department, however, her condition evolved unfavorably. GC with restricted bone metastasis is rare at presentation and has a poor prognosis. Despite its infrequency, clinicians should consider GC involvement when evaluating secondary suspicious bone lesions.
摘要：
胃癌(GC)是全球范围内关注的主要健康状况,以印戒细胞为特征的胃癌越来越多的报道。一名61岁的妇女因背痛被送往急诊科,肠胃不适,和减肥。进行了腰椎和髋部计算机断层扫描（CT），发现多个可疑的继发性骨病变。实验室检查结果报告贫血，血小板减少症,碱性磷酸酶升高.胸-腹-盆CT,脊柱上可见多个提示转移的骨病变，肋骨,骨盆骨,和股骨近端,但未描述可识别的原发性或内脏病变。上镜检查发现胃腺癌，以及胃和骨的病变，尤其是骨损伤,包含相关量的印戒细胞。病人被转诊到肿瘤内科,然而,她的病情发展不利。伴有限制性骨转移的GC很少见，预后较差。尽管频率不高，临床医师在评估继发性可疑骨病变时应考虑GC受累.
