PDF(Pubmed)
Abstract：
Some previous case reports have implied a relationship between acromegaly and ossification of the spinal ligaments. However, there have been no reports of a case series exploring the incidence of ossification of the spinal ligaments in patients with acromegaly. To this end, computed tomography (CT) of the spine in 10 consecutive patients with acromegaly was examined in this study. Five out of 10 patients had ossification of the spinal ligaments. Among them, two patients had ossification of the posterior longitudinal ligament (OPLL), which was noticeably higher than the prevalence of OPLL in the general adult population (1.9-4.3 %). Body mass index was significantly higher in the group with spinal ligament ossification (p = 0.03), but there were no significant differences in age, sex, serum phosphate, albumin-adjusted calcium, growth hormone (GH), standard deviation of insulin-like growth factor-1 (IGF-1), or the incidence of diabetes mellitus between the groups with or without ossification of the spinal ligaments. The ossification index (OS index) was used to determine the severity of spinal ligament ossification, and there were no significant correlations between the OS index and GH or IGF-1 (p = 0.51 and 0.75, respectively). This study was the first to report a high prevalence of spinal ossification in patients with acromegaly. In conclusion, this study suggested a possible association between acromegaly and ossification of the spinal ligaments, although the number of patients was insufficient to draw a conclusion. Acromegaly patients should be tested to confirm, or rule out, spinal ossification, and further studies to clarify the underlying mechanism of spinal ossification in acromegaly patients are warranted.
摘要：
以前的一些病例报告暗示肢端肥大症与脊髓韧带骨化之间存在关系。然而,目前尚无病例系列报道探讨肢端肥大症患者脊髓韧带骨化的发生率。为此,本研究对10例连续肢端肥大症患者的脊柱计算机断层扫描(CT)进行了检查.10例患者中有5例脊髓韧带骨化。其中,两名患者后纵韧带骨化（OPLL），明显高于普通成人人群中OPLL的患病率（1.9-4.3％）。脊柱韧带骨化组的体重指数明显增高(p=0.03),但是年龄没有显著差异，性别,血清磷酸盐，白蛋白调节钙，生长激素（GH），胰岛素样生长因子-1（IGF-1）的标准偏差，或有或没有脊髓韧带骨化的组间糖尿病的发病率。骨化指数（OS指数）用于确定脊柱韧带骨化的严重程度，OS指数与GH或IGF-1之间没有显着相关性（分别为p=0.51和0.75）。这项研究首次报道了肢端肥大症患者脊柱骨化的高患病率。总之,这项研究表明肢端肥大症与脊髓韧带骨化之间可能存在关联，尽管患者人数不足以得出结论。肢端肥大症患者应进行检查以确认，或者排除，脊髓骨化,有必要进一步研究以阐明肢端肥大症患者脊髓骨化的潜在机制。
