Abstract：
Cancer seriously threatens human health. Surgery, radiotherapy and chemotherapy are the three pillars of traditional cancer treatment, with targeted therapy and immunotherapy emerging over recent decades. Standard drug regimens are mostly executed via intravenous injection (IV), especially for chemotherapy agents. However, these treatments pose severe risks, including off-target toxic side effects, low drug accumulation and penetration at the tumor site, repeated administration, etc., leading to inadequate treatment and failure to meet patients\' needs. Arising from these challenges, a local regional anticancer strategy has been proposed to enhance therapeutic efficacy and concomitantly reduce systemic toxicity. With the advances in biomaterials and our understanding of the tumor microenvironment, in situ stimulus-responsive hydrogels, also called smart hydrogels, have been extensively investigated for local anticancer therapy due to their injectability, compatibility and responsiveness to various stimuli (pH, enzyme, heat, light, magnetic fields, electric fields etc.). Herein, we focus on the latest progress regarding various stimuli that cause phase transition and drug release from smart hydrogels in local regional anticancer therapy. Additionally, the challenges and future trends of the reviewed in situ smart hydrogels for local drug delivery are summarized and proposed.
摘要：
癌症严重威胁人类健康。手术,放疗和化疗是传统癌症治疗的三大支柱，随着近几十年来靶向治疗和免疫疗法的出现。标准药物方案主要通过静脉注射（IV）执行，尤其是化疗药物。然而,这些治疗会带来严重的风险，包括脱靶毒副作用，在肿瘤部位的药物积累和渗透低，重复给药,等。,导致治疗不足和无法满足患者需求。由于这些挑战，已提出了一种局部区域抗癌策略，以增强治疗效果并同时降低全身毒性。随着生物材料的进步和我们对肿瘤微环境的认识,原位刺激响应水凝胶，也被称为智能水凝胶，由于其可注射性，已被广泛研究用于局部抗癌治疗，对各种刺激(pH，酶，热,光,磁场,电场等。).在这里，我们重点介绍了在局部区域抗癌治疗中，智能水凝胶引起相变和药物释放的各种刺激的最新进展。此外,总结并提出了用于局部给药的原位智能水凝胶的挑战和未来趋势。
