PDF(Pubmed)
Abstract：
An adequate and balanced supply of nutrients is essential for maintaining health, and an optimal immune response is fast, contained and properly controlled, curbing infections quickly while minimizing damage. Several micronutrients contribute to normal immune function and certain dietary fibers, for example pectic polysaccharides, can play an important role in educating and regulating immune cell responses. The aim of this paper is to elaborate on our initial findings that dietary supplementation with carrot-derived rhamnogalacturonan-I (cRG-I) accelerates and augments local innate immune and anti-viral interferon response to a rhinovirus-16 (RV16) infection and reduces the severity and duration of symptoms in humans. Dietary intake of cRG-I also enhanced immune responses to this respiratory viral infection as measured by ex vivo stimulation of whole blood with the Toll-like receptor 3 (TLR3) ligand polyinosinic:polycytidylic acid and NK cell function. Consumption of cRG-I also reduced the negative effects of this common cold infection on quality of life as assessed by individual symptom scores. RG-I from carrot is a safe, sustainable, and economically viable solution that could easily be integrated into food products and dietary supplements aiming to support immune fitness and wellbeing.
摘要：
充足和平衡的营养供应对于保持健康至关重要，最佳的免疫反应是快速的，包含并适当控制，迅速遏制感染，同时尽量减少损害。几种微量营养素有助于正常的免疫功能和某些膳食纤维，例如果胶多糖，可以在教育和调节免疫细胞反应中发挥重要作用。本文的目的是详细阐述我们的初步发现，即膳食补充胡萝卜衍生的鼠李糖半乳糖醛酸-I（cRG-I）可加速和增强局部先天免疫和抗病毒干扰素对鼻病毒16（RV16）感染的反应，并减少人类症状的严重程度和持续时间。如通过用Toll样受体3(TLR3)配体聚肌苷酸:聚胞苷酸对全血的离体刺激和NK细胞功能所测量的,cRG-I的饮食摄入也增强了对这种呼吸道病毒感染的免疫应答。cRG-I的消耗还降低了这种普通感冒感染对生活质量的负面影响,如通过个体症状评分所评估的。胡萝卜的RG-I是保险箱，可持续,和经济上可行的解决方案，可以很容易地整合到食品和膳食补充剂，旨在支持免疫健康和福祉。
