Abstract：
Sesterterpenes are 25-carbon terpenoids formed by the cyclization of dimethyl allyl diphosphate (DMAPP) and isopentenyl diphosphate (IPP) as structural units by sesterterpenes synthases. Some (not all) sesterterpenoids are modified by cytochrome P450s (CYP450s), resulting in more intricate structures. These compounds have significant physiological activities and pharmacological effects in anti-inflammatory, antibacterial, antitumour, and hypolipidemic communities. Despite being a rare class of terpenoids, sesterterpenoids derived from fungi show a wide range of structural variations. The discovered fungal sesterterpenoid synthases are composed of C-terminal prenyltransferase (PT) and N-terminal terpene synthase (TS) domains, which were given the name PTTSs. PTTSs have the capacities to catalyze chain lengthening and cyclization concurrently. This review summarizes all 52 fungal PTTSs synthases and their biosynthetic pathways involving 100 sesterterpenoids since the discovery of the first PTTSs synthase from fungi in 2013.
摘要：
酯萜烯是通过酯萜烯合酶将二甲基烯丙基二磷酸（DMAPP）和异戊烯基二磷酸（IPP）环化为结构单元而形成的25碳萜类化合物。一些（不是全部）类脂被细胞色素P450（CYP450）修饰，导致更复杂的结构。这些化合物在抗炎方面具有显著的生理活性和药理作用,抗菌，抗肿瘤，和降血脂社区。尽管是一类罕见的萜类化合物，来自真菌的类酯萜类化合物显示出广泛的结构变异。已发现的真菌类脂萜类合酶由C末端异戊烯基转移酶（PT）和N末端萜类合酶（TS）结构域组成，被命名为PTTS。PTTS具有同时催化链延长和环化的能力。这篇综述总结了自2013年发现第一个来自真菌的PTTSs合酶以来，所有52种真菌PTTSs合酶及其生物合成途径，涉及100种皮萜类化合物。
