关键词: antibody antigen blastomycosis coccidioidomycosis cryptococcosis emergomycosis histoplasmosis paracoccidioidomycosis sporotrichosis talaromycosis

来  源:   DOI:10.3390/jof8100993

Abstract:
The endemic mycoses blastomycosis, coccidioidomycosis, histoplasmosis, paracoccidioidomycosis, cryptococcosis, sporotrichosis, talaromycosis, adiaspiromycosis, and emergomycosis are mostly caused by geographically limited thermally dimorphic fungi (except for cryptococcosis), and their diagnoses can be challenging. Usual laboratory methods involved in endemic mycoses diagnosis include microscopic examination and culture of biological samples; however, serologic, histopathologic, and molecular techniques have been implemented in the last few years for the diagnosis of these mycoses since the recovery and identification of their etiologic agents is time-consuming and lacks in sensitivity. In this review, we focus on the immunologic diagnostic methods related to antibody and antigen detection since their evidence is presumptive diagnosis, and in some mycoses, such as cryptococcosis, it is definitive diagnosis.
摘要:
地方性真菌病芽生菌病,球孢子菌病,组织胞浆菌病,副角菌病,隐球菌病,孢子丝菌病,塔拉真菌病,非肉芽肿病,和真菌病主要是由地理上有限的热二形真菌引起的(隐球菌病除外),他们的诊断可能具有挑战性。地方性真菌病诊断中涉及的通常实验室方法包括显微镜检查和生物样品的培养;然而,血清学,组织病理学,在过去的几年中,已经实施了分子技术来诊断这些真菌病,因为它们的病原体的恢复和鉴定耗时且缺乏敏感性。在这次审查中,我们专注于与抗体和抗原检测相关的免疫诊断方法,因为它们的证据是推定诊断,在一些真菌病中,比如隐球菌病,这是明确的诊断。
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