Abstract：
Chronic nodular prurigo (CNPG) is a recalcitrant chronic itchy disorder that affects the quality of life. It can be triggered by multiple etiologies, such as atopic dermatitis, diabetes, and chronic renal diseases. The mechanisms of CNPG are complicated and involved the interaction of the cutaneous, immune, and nervous systems. Diverse immune cells, including eosinophils, neutrophils, T cells, macrophages, and mast cells infiltrated the lesional skin of CNPG, which initiated the inflammatory cytokines and pruritogens release. In addition, the interaction between the immune cells and activated peripheral sensory nerve fibers by neurotransmitters caused neuroinflammation in the skin and intractable itch. This itch-scratch vicious cycle of CNPG results in disease exacerbation. CNPG is difficult to treat with traditional therapies. Recently, great advances have been made in the pathophysiology of both inflammation and pruritus transmission in CNPG. In this review, we summarize the updated mechanisms and novel therapies for CNPG.
摘要：
慢性结节性痒疹（CNPG）是一种顽固性慢性瘙痒疾病，影响生活质量。它可以由多种病因引发，如特应性皮炎，糖尿病,和慢性肾脏疾病。CNPG的机制复杂，涉及皮肤的相互作用，免疫，和神经系统。多种免疫细胞，包括嗜酸性粒细胞,中性粒细胞，T细胞,巨噬细胞，肥大细胞浸润了CNPG的皮损,这引发了炎症细胞因子和瘙痒原的释放。此外,免疫细胞与激活的周围感觉神经纤维之间的相互作用通过神经递质引起皮肤神经炎症和顽固性瘙痒。CNPG的这种瘙痒-抓痒的恶性循环导致疾病恶化。CNPG难以用传统疗法治疗。最近,CNPG在炎症和瘙痒传播的病理生理学方面都取得了很大进展。在这次审查中,我们总结了CNPG的最新机制和新疗法。
