Abstract：
Integrins are necessary for cell adhesion, migration, and positioning. Essential for inducing signalling events for cell survival, proliferation, and differentiation, they also trigger a variety of signal transduction pathways involved in mediating invasion, metastasis, and squamous-cell carcinoma. Several recent studies have demonstrated that the up- and down-regulation of the expression of αv and other integrins can be a potent marker of malignant diseases and patient prognosis. This review focuses on an arginine-glycine-aspartic acid (RGD)-dependent integrin αVβ6, its biology, and its role in healthy humans. We examine the implications of αVβ6 in cancer progression and the promotion of epithelial-mesenchymal transition (EMT) by contributing to the activation of transforming growth factor beta TGF-β. Although αvβ6 is crucial for proper function in healthy people, it has also been validated as a target for cancer treatment. This review briefly considers aspects of targeting αVβ6 in the clinic via different therapeutic modalities.
摘要：
整合素是细胞粘附所必需的，迁移,和定位。对于诱导细胞存活的信号事件至关重要，扩散,和差异化，它们还触发多种参与介导入侵的信号转导途径，转移,和鳞状细胞癌.最近的几项研究表明，αv和其他整合素表达的上调和下调可能是恶性疾病和患者预后的有效标志物。本文对精氨酸-甘氨酸-天冬氨酸(RGD)依赖性整合素αVβ6、以及它在健康人类中的作用。我们通过促进转化生长因子βTGF-β的激活来研究αVβ6在癌症进展和促进上皮间质转化（EMT）中的意义。虽然αvβ6对健康人的正常功能至关重要，它也已被验证为癌症治疗的靶标。这篇综述简要考虑了通过不同治疗方式在临床上靶向αVβ6的方面。
