Abstract：
The lysyl oxidase (LOX) family, consisting of LOX and LOX-like proteins 1-4 (LOXL1-4), is responsible for the covalent crosslinking of collagen and elastin, thus maintaining the stability of the extracellular matrix (ECM) and functioning in maintaining connective tissue function, embryonic development, and wound healing. Recent studies have found the aberrant expression or activity of the LOX family occurs in various types of cancer. It has been proved that the LOX family mainly performs tumor microenvironment (TME) remodeling function and is extensively involved in tumor invasion and metastasis, immunomodulation, proliferation, apoptosis, etc. With relevant translational research in progress, the LOX family is expected to be an effective target for tumor therapy. Here, we review the research progress of the LOX family in tumor progression and therapy to provide novel insights for future exploration of relevant tumor mechanism and new therapeutic targets.
摘要：
赖氨酰氧化酶(LOX)家族,由LOX和LOX样蛋白1-4（LOXL1-4）组成，负责胶原蛋白和弹性蛋白的共价交联，从而维持细胞外基质（ECM）的稳定性和维持结缔组织功能的功能，胚胎发育,伤口愈合。最近的研究已经发现LOX家族的异常表达或活性发生在各种类型的癌症中。已经证明，LOX家族主要执行肿瘤微环境（TME）的重塑功能，广泛参与肿瘤的侵袭和转移，免疫调节,扩散,凋亡，等。随着相关转化研究的进展，LOX家族有望成为肿瘤治疗的有效靶点。这里,本文对LOX家族在肿瘤进展和治疗方面的研究进展进行综述，为今后探索相关肿瘤机制和新的治疗靶点提供新的见解。
