Abstract：
Cell-cell junctions comprise various structures, including adherens junctions, tight junctions, desmosomes, and gap junctions. They link cells to each other in tissues and regulate tissue homeostasis in critical cellular processes. Recent advances in cell-cell junction research have led to critical discoveries. Cell-cell adhesion components are important for the invasion and metastasis of tumour cells, which are not only related to cell-cell adhesion changes, but they are also involved in critical molecular signal pathways. They are of great significance, especially given that relevant molecular mechanisms are being discovered, there are an increasing number of emerging biomarkers, targeted therapies are becoming a future therapeutic concern, and there is an increased number of therapeutic agents undergoing clinical trials. Oesophageal squamous cell carcinoma (ESCC), the most common histological subtype of oesophageal cancer, is one of the most common cancers to affect epithelial tissue. ESCC progression is accompanied by the abnormal expression or localisation of components at cell-cell junctions. This review will discuss the recent scientific developments related to the molecules at cell-cell junctions and their role in ESCC to offer valuable insights for readers, provide a global view of the relationships between position, construction, and function, and give a reference for future mechanistic studies, diagnoses, and therapeutic developments.
摘要：
细胞-细胞连接包括各种结构，包括粘附点，紧密连接，桥粒,和缝隙连接。它们在组织中将细胞彼此连接，并在关键的细胞过程中调节组织稳态。细胞-细胞连接研究的最新进展导致了重要的发现。细胞-细胞粘附成分对于肿瘤细胞的侵袭和转移是重要的,这不仅与细胞-细胞粘附变化有关，但它们也参与关键的分子信号通路。它们意义重大,特别是考虑到相关的分子机制正在被发现，有越来越多的新兴生物标志物，靶向治疗正在成为未来的治疗关注点，并且正在进行临床试验的治疗剂数量增加。食管鳞状细胞癌(ESCC),食管癌最常见的组织学亚型，是影响上皮组织的最常见癌症之一。ESCC进展伴随着细胞-细胞连接处组分的异常表达或定位。这篇综述将讨论与细胞-细胞连接分子相关的最新科学发展及其在ESCC中的作用，为读者提供有价值的见解。提供位置之间关系的全局视图，建筑,和功能，为今后的机理研究提供参考,诊断,和治疗发展。
