Abstract：
BACKGROUND: Facial paralysis (FP) is a common symptom after stroke, which influences the quality of life and prognosis of patients. Recently, peripheral magnetic stimulation (PMS) shows potential effects on peripheral and central nervous system damage. However, the effect of PMS on FP after stroke is still unclear.
METHODS: In this study, we applied PMS on the facial nerve of nine stroke patients with FP. At the same time, laser speckle contrast imaging (LSCI) was used to explore the facial skin blood flow (SkBF) in 19 healthy subjects and nine stroke patients with FP before and after the PMS intervention. The whole face was divided into 14 regions to compare the SkBF in different sub-areas.
RESULTS: In baseline SkBF, we found that there were no significant differences in the SkBF between the left and right faces in the healthy subjects. However, there was a significant difference in the SkBF between the affected and unaffected faces in Region 7 (Chin area, p = 0.046). In the following five minutes after the PMS intervention (Pre_0-5 min), the SkBF increased in Region 5 (p = 0.014) and Region 7 (p = 0.046) and there was an increasing trend in Region 3 (p = 0.088) and Region 6 (p = 0.069). In the five to ten minutes after the intervention (Post_6-10 min), the SkBF increased in Region 5 (p = 0.009), Region 6 (p = 0.021) and Region 7 (p = 0.023) and there was an increasing trend in Region 3 (p = 0.080) and left and right whole face (p = 0.051).
CONCLUSIONS: These pilot results indicate that PMS intervention could increase facial skin blood flow in stroke patients with FP. A further randomized controlled trial can be performed to explore its possible clinical efficacy.
METHODS: In this study, we applied PMS on the facial nerve of nine stroke patients with FP. At the same time, laser speckle contrast imaging (LSCI) was used to explore the facial skin blood flow (SkBF) in 19 healthy subjects and nine stroke patients with FP before and after the PMS intervention. The whole face was divided into 14 regions to compare the SkBF in different sub-areas.
RESULTS: In baseline SkBF, we found that there were no significant differences in the SkBF between the left and right faces in the healthy subjects. However, there was a significant difference in the SkBF between the affected and unaffected faces in Region 7 (Chin area, p = 0.046). In the following five minutes after the PMS intervention (Pre_0-5 min), the SkBF increased in Region 5 (p = 0.014) and Region 7 (p = 0.046) and there was an increasing trend in Region 3 (p = 0.088) and Region 6 (p = 0.069). In the five to ten minutes after the intervention (Post_6-10 min), the SkBF increased in Region 5 (p = 0.009), Region 6 (p = 0.021) and Region 7 (p = 0.023) and there was an increasing trend in Region 3 (p = 0.080) and left and right whole face (p = 0.051).
CONCLUSIONS: These pilot results indicate that PMS intervention could increase facial skin blood flow in stroke patients with FP. A further randomized controlled trial can be performed to explore its possible clinical efficacy.
摘要：
背景：面瘫（FP）是中风后的常见症状，影响患者的生活质量和预后。最近,外周磁刺激（PMS）对外周和中枢神经系统的损害具有潜在的影响。然而,PMS对卒中后FP的影响尚不清楚。
方法：在本研究中，我们在9例中风FP患者的面神经上应用了PMS。同时,采用激光散斑对比成像（LSCI）技术，对19例健康受试者和9例中风患者进行PMS干预前后的面部皮肤血流量（SkBF）进行了研究。将整个面部分为14个区域，以比较不同子区域中的SkBF。
结果：在基线SkBF中，我们发现，在健康受试者中，左脸和右脸之间的SkBF没有显着差异。然而,在第7区，受影响和未受影响的面孔之间的SkBF存在显着差异（Chin地区，p=0.046)。在PMS干预后的五分钟内（Pre_0-5分钟），SkBF在区域5（p=0.014）和区域7（p=0.046）中增加，并且在区域3（p=0.088）和区域6（p=0.069）中增加。在干预后的5到10分钟(后6-10分钟)，区域5的SkBF增加(p=0.009)，区域6(p=0.021)和区域7(p=0.023),并且在区域3(p=0.080)和左右整个面部(p=0.051)中存在增加趋势。
结论：这些初步结果表明，PMS干预可以增加FP卒中患者的面部皮肤血流量。可以进行进一步的随机对照试验以探索其可能的临床疗效。
方法：在本研究中，我们在9例中风FP患者的面神经上应用了PMS。同时,采用激光散斑对比成像（LSCI）技术，对19例健康受试者和9例中风患者进行PMS干预前后的面部皮肤血流量（SkBF）进行了研究。将整个面部分为14个区域，以比较不同子区域中的SkBF。
结果：在基线SkBF中，我们发现，在健康受试者中，左脸和右脸之间的SkBF没有显着差异。然而,在第7区，受影响和未受影响的面孔之间的SkBF存在显着差异（Chin地区，p=0.046)。在PMS干预后的五分钟内（Pre_0-5分钟），SkBF在区域5（p=0.014）和区域7（p=0.046）中增加，并且在区域3（p=0.088）和区域6（p=0.069）中增加。在干预后的5到10分钟(后6-10分钟)，区域5的SkBF增加(p=0.009)，区域6(p=0.021)和区域7(p=0.023),并且在区域3(p=0.080)和左右整个面部(p=0.051)中存在增加趋势。
结论：这些初步结果表明，PMS干预可以增加FP卒中患者的面部皮肤血流量。可以进行进一步的随机对照试验以探索其可能的临床疗效。
