PDF(Pubmed)
Abstract：
Atherosclerosis is a chronic widespread cardiovascular disease and a major predisposing factor for cardiovascular events, among which there are myocardial infarction and ischemic stroke. Atherosclerotic plaque formation is a process that involves different mechanisms, of which inflammation is the most common. Plenty of radiopharmaceuticals were developed to elucidate the process of plaque formation at different stages, some of which were highly specific for atherosclerotic plaque. This review summarizes the current nuclear medicine imaging landscape of preclinical and small-scale clinical studies of these specific RPs, which are not as widespread as labeled FDG, sodium fluoride, and choline. These include oxidation-specific epitope imaging, macrophage, and other cell receptors visualization, neoangiogenesis, and macrophage death imaging. It is shown that specific radiopharmaceuticals have strength in pathophysiologically sound imaging of the atherosclerotic plaques at different stages, but this also may induce problems with the signal registration for low-volume plaques in the vascular wall.
摘要：
动脉粥样硬化是一种慢性广泛分布的心血管疾病，是心血管事件的主要诱发因素，其中有心肌梗死和缺血性中风。动脉粥样硬化斑块形成是一个涉及不同机制的过程，其中炎症是最常见的。开发了大量的放射性药物来阐明不同阶段的斑块形成过程，其中一些对动脉粥样硬化斑块具有高度特异性。这篇综述总结了这些特定RP的临床前和小规模临床研究的当前核医学成像景观，没有标签FDG那么普遍，氟化钠,还有胆碱.这些包括氧化特异性表位成像，巨噬细胞,和其他细胞受体可视化，新血管生成,和巨噬细胞死亡成像。结果表明，特定的放射性药物在不同阶段的动脉粥样硬化斑块的病理生理声音成像中具有强度，但这也可能导致血管壁中低体积斑块的信号配准问题。
