PDF(Pubmed)
Abstract：
This literature review investigates the significant overlap between myelin-repair signaling pathways and pathways known to contribute to hallmark pathologies of Alzheimer\'s disease (AD). We discuss previously investigated therapeutic targets of amyloid, tau, and ApoE, as well as other potential therapeutic targets that have been empirically shown to contribute to both remyelination and progression of AD. Current evidence shows that there are multiple AD-relevant pathways which overlap significantly with remyelination and myelin repair through the encouragement of oligodendrocyte proliferation, maturation, and myelin production. There is a present need for a single, cohesive model of myelin homeostasis in AD. While determining a causative pathway is beyond the scope of this review, it may be possible to investigate the pathological overlap of myelin repair and AD through therapeutic approaches.
摘要：
这篇文献综述研究了髓鞘修复信号通路和已知有助于阿尔茨海默病(AD)标志性病理的通路之间的显著重叠。我们讨论了先前研究的淀粉样蛋白的治疗靶标，tau,和Apoe,以及经验证明有助于AD髓鞘再生和进展的其他潜在治疗靶标。目前的证据表明，有多种AD相关途径，通过促进少突胶质细胞增殖，与髓鞘再生和髓鞘修复显着重叠。成熟,和髓鞘生产。目前需要一个单一的，AD髓鞘内稳态的内聚模型。虽然确定致病途径超出了本综述的范围，有可能通过治疗方法研究髓鞘修复和AD的病理重叠。
