Abstract：
Surgical resection of solid tumours, especially in early stages of disease, remains a cornerstone of cancer treatment in dogs and cats. There are numerous publications that show a strong association between local tumour control and outcome. To achieve local control in some cases radiation therapy and surgery are combined, with radiation therapy being delivered in the neoadjuvant or adjuvant setting. The objective of the study was to report acute toxicity and surgical site complication data in dogs that received a short-course pre-operative (SCPO) radiation therapy protocol, followed by surgical excision for various solid tumours. Medical records were reviewed, and data was analysed retrospectively. Dogs were included if a dermal or subcutaneous solid tumour was treated with SCPO radiation therapy and then was resected on the last day of radiation or 2-3 weeks later. A total of 34 dogs with 35 primary tumours were included. Acute radiation toxicity was diagnosed in 14 sites (40%). VRTOG scores were grade 1 in 50%, grade 2 in 43%, and grade 3 in 7%. Surgical site complications were identified in 17% of dogs with an overall surgical site infection rate of 11%. According to the Clavien-Dindo classification, two dogs required medical intervention (grade 2), 1 dog required surgical intervention under general anaesthesia (grade 3b), and 1 dog died as a result of complications (grade 5). Logistic regression analysis found that anatomic site was significantly associated with complications, where tumours located on the extremity was protective (P = .02; OR 0.06).
摘要：
实体瘤的手术切除，尤其是在疾病的早期阶段，仍然是狗和猫癌症治疗的基石。有许多出版物显示局部肿瘤控制和结果之间的强关联。为了实现局部控制，在某些情况下将放射治疗和手术相结合，放射治疗是在新辅助或辅助环境中进行的。该研究的目的是报告接受短期术前（SCPO）放射治疗方案的狗的急性毒性和手术部位并发症数据，然后手术切除各种实体瘤。检查了医疗记录,并对数据进行回顾性分析。如果用SCPO放射疗法治疗真皮或皮下实体瘤，然后在放射的最后一天或2-3周后切除，则包括狗。包括总共34只具有35个原发性肿瘤的狗。在14个地点（40％）诊断出急性辐射毒性。VRTOG分数为1级，占50%，43%的2级，和3级的7%。在17％的狗中发现了手术部位并发症，总体手术部位感染率为11％。根据Clavien-Dindo分类，两只狗需要医疗干预（2级），1只狗需要在全身麻醉下进行手术干预（3b级），1只狗死于并发症（5级）。Logistic回归分析发现解剖部位与并发症显著相关,位于四肢的肿瘤具有保护性（P=0.02；OR0.06）。
