Abstract：
Eight new cyclopiazonic acid (1-8) and five new okaramine (9-13) alkaloids together with 13 known compounds were isolated from the fungus Chrysosporium undulatum YT-1. Compounds 2, 4, 5, 7, 10, 11, and 13 were chlorinated indole alkaloids. The structures of compounds 1-13 were elucidated by HRESIMS and NMR spectroscopic data. Their relative and absolute configurations were established by J-based configuration analysis, NOESY, NOEDIFF experiments, ECD spectroscopic data, and biogenetic considerations. Compound 4 inhibited the growth of Bacillus subtilis with an MIC value of 6.3 μg/mL. Compounds 9-11 exhibited strong insecticidal capacity against the third instar larvae of silkworm and cotton bollworm (LD50: ≤7.56 μg/g). At 40 μM, compound 1 showed obvious neuroprotection to the PC12 cells with 6-OHDA treatment.
摘要：
从真菌黄孢子菌YT-1中分离出八种新的环吡嗪酸（1-8）和五种新的可卡胺（9-13）生物碱以及13种已知化合物。化合物2、4、5、7、10、11和13为氯化吲哚生物碱。化合物1-13的结构通过HRESIMS和NMR光谱数据阐明。通过基于J的构型分析建立了它们的相对构型和绝对构型，鼻子,NOEDIFF实验，ECD光谱数据，和生物遗传学的考虑。化合物4抑制枯草芽孢杆菌的生长,MIC值为6.3μg/mL。化合物9-11对家蚕和棉铃虫三龄幼虫表现出较强的杀虫能力(LD50:≤7.56μg/g)。在40μM时，化合物1对6-OHDA处理的PC12细胞具有明显的神经保护作用。
