PDF(Pubmed)
Abstract：
This study reported a case of a Rhino-Orbital-Cerebral Mycosis (ROCM) patient with multiple groups of cranial nerve damage as the primary clinical manifestation, confirmed by histopathology and cerebrospinal fluid metagenomic next-generation sequencing (mNGS) technology. Relying on the MRI3D-SPACE technology, we observed the location and extent of the cranial nerve damage in the patient. The results suggested that fungal meningoencephalitis caused by mucor may enter the skull retrograde along the cranial nerve perineurium. The patient was admitted to the hospital with a preliminary diagnosis of mucormycosis infection after 1.5 days of mouth deviation. We treated the patient immediately with intravenous amphotericin B liposomes. After 21 days of hospitalization, the clinical symptoms of the patient did not improve significantly. The patient was discharged due to financial difficulties and antifungal treatment at home, and his disease had stabilized at the 6-month follow-up.
摘要：
本研究报告1例以多组脑神经损害为主要临床表现的犀牛-眼眶-脑真菌病(ROCM)患者,通过组织病理学和脑脊液宏基因组下一代测序（mNGS）技术证实。依靠MRI3D-SPACE技术,我们观察了患者脑神经损伤的位置和程度。结果提示，由黏液引起的真菌性脑膜脑炎可能沿颅神经会阴周围逆行进入颅骨。患者在口腔偏斜1.5天后入院，初步诊断为毛霉菌病感染。我们立即用静脉注射两性霉素B脂质体治疗患者。住院21天后，患者的临床症状没有明显改善。病人因经济困难及在家抗真菌治疗而出院,他的病情在6个月的随访中稳定下来.
