PDF(Pubmed)
Abstract：
UNASSIGNED: Prior studies of mindfulness meditation have demonstrated anti-inflammatory and immunoregulatory effects but whether meditation courses delivered online can exert similar effects is poorly understood. Barriers to large scale implementation of traditional mindfulness meditation programs has created an increased interest in the effect of less time- and resource-intensive online meditation courses. The purpose of this study was to determine whether a 6-week online mindfulness program with low time demands on nurses would lead to changes in gene expression, cytokine profiles, telomerase activity, and cortisol profiles.
UNASSIGNED: This was a randomized, parallel pilot study comparing an online mindfulness-based stress management program to an active control group from December 2018 to May 2019. Healthy nurses with above average levels of perceived stress were randomized to receive a 6-week online mindfulness-based stress management program including ≥5 min daily meditation practice or listen to relaxing music for ≥5 min daily as the control arm. Blood samples were collected at baseline and after 6 weeks, and various self-reported measures of stress, physical and emotional health were collected at baseline, after 6 weeks, and after 12 weeks. Whole transcriptome mRNA sequencing of whole blood at baseline and after 6 weeks was performed along with measurement of plasma IL-6, IL-8, IL-10, TNF-α, and IFN-γ. Peripheral blood mononuclear cells were isolated, and telomerase activity was measured. Diurnal salivary cortisol profiles were assessed at baseline and after 6 weeks. The primary outcome was change over time in a pre-determined set of 53 genes representative of the immune-related changes seen with stress, which was analyzed using a mixed linear model. Secondary outcomes included all other self-reported measures and biomarkers mentioned above.
UNASSIGNED: A total of 61 nurses were randomized, with 52 having sufficient data to include in the final analysis. After 6 weeks, nurses in the control group reported significant reductions in stress as measured by the Perceived Stress Scale while those in the mindfulness group did not. However, after 12 weeks, the mindfulness group also showed a significant reduction in stress. When compared to the control group, no significant changes in RNA gene expression or any other biomarkers were observed in the nurses who participated in the mindfulness program.
UNASSIGNED: Our study found that this brief online mindfulness-based intervention was effective in reducing stress in nurses, albeit with a delayed effect compared to listening to relaxing music. Regarding immunoregulatory effects, there were no significant differences between treatment and control groups in transcriptomic or other tested biomarkers of immune function. This study provides evidence for a floor effect of mindfulness on transcriptional and circulating biomarkers of immune function.
UNASSIGNED: This was a randomized, parallel pilot study comparing an online mindfulness-based stress management program to an active control group from December 2018 to May 2019. Healthy nurses with above average levels of perceived stress were randomized to receive a 6-week online mindfulness-based stress management program including ≥5 min daily meditation practice or listen to relaxing music for ≥5 min daily as the control arm. Blood samples were collected at baseline and after 6 weeks, and various self-reported measures of stress, physical and emotional health were collected at baseline, after 6 weeks, and after 12 weeks. Whole transcriptome mRNA sequencing of whole blood at baseline and after 6 weeks was performed along with measurement of plasma IL-6, IL-8, IL-10, TNF-α, and IFN-γ. Peripheral blood mononuclear cells were isolated, and telomerase activity was measured. Diurnal salivary cortisol profiles were assessed at baseline and after 6 weeks. The primary outcome was change over time in a pre-determined set of 53 genes representative of the immune-related changes seen with stress, which was analyzed using a mixed linear model. Secondary outcomes included all other self-reported measures and biomarkers mentioned above.
UNASSIGNED: A total of 61 nurses were randomized, with 52 having sufficient data to include in the final analysis. After 6 weeks, nurses in the control group reported significant reductions in stress as measured by the Perceived Stress Scale while those in the mindfulness group did not. However, after 12 weeks, the mindfulness group also showed a significant reduction in stress. When compared to the control group, no significant changes in RNA gene expression or any other biomarkers were observed in the nurses who participated in the mindfulness program.
UNASSIGNED: Our study found that this brief online mindfulness-based intervention was effective in reducing stress in nurses, albeit with a delayed effect compared to listening to relaxing music. Regarding immunoregulatory effects, there were no significant differences between treatment and control groups in transcriptomic or other tested biomarkers of immune function. This study provides evidence for a floor effect of mindfulness on transcriptional and circulating biomarkers of immune function.
摘要：
UNASSIGNED：关于正念冥想的先前研究已经证明了抗炎和免疫调节作用，但是在线提供的冥想课程是否可以发挥类似的作用却知之甚少。大规模实施传统正念冥想计划的障碍增加了人们对时间和资源密集型在线冥想课程的影响的兴趣。这项研究的目的是确定对护士的时间要求低的6周在线正念计划是否会导致基因表达的变化，细胞因子谱，端粒酶活性，和皮质醇档案。
未经批准：这是一个随机的，从2018年12月至2019年5月，将基于在线正念的压力管理计划与主动对照组进行比较的平行试点研究。具有高于平均水平的感知压力的健康护士被随机接受为期6周的基于在线正念的压力管理计划，包括每天≥5分钟的冥想练习或每天听放松音乐≥5分钟作为控制臂。在基线和6周后收集血液样本，和各种自我报告的压力测量，在基线时收集身体和情绪健康，6周后,12周后。在基线和6周后进行全血的全转录组mRNA测序，同时测量血浆IL-6，IL-8，IL-10，TNF-α，和IFN-γ。分离外周血单核细胞，并测定端粒酶活性。在基线和6周后评估昼夜唾液皮质醇谱。主要结果是一组预先确定的53个基因随时间的变化，这些基因代表了与压力有关的免疫相关变化。这是使用混合线性模型进行分析的。次要结果包括上述所有其他自我报告的测量和生物标志物。
未经评估：共有61名护士被随机分配，52有足够的数据包括在最终分析中。6周后,对照组的护士报告了通过感知压力量表测量的压力显着降低，而正念组的护士则没有。然而,12周后,正念组的压力也显著减少。与对照组相比，在参与正念计划的护士中,未观察到RNA基因表达或任何其他生物标志物的显著变化.
UNASSIGNED：我们的研究发现，这种简短的基于在线正念的干预措施可以有效地减轻护士的压力，尽管与听轻松的音乐相比有延迟的效果。关于免疫调节作用，治疗组和对照组在转录组或其他免疫功能检测生物标志物方面没有显著差异.这项研究为正念对免疫功能的转录和循环生物标志物的影响提供了证据。
未经批准：这是一个随机的，从2018年12月至2019年5月，将基于在线正念的压力管理计划与主动对照组进行比较的平行试点研究。具有高于平均水平的感知压力的健康护士被随机接受为期6周的基于在线正念的压力管理计划，包括每天≥5分钟的冥想练习或每天听放松音乐≥5分钟作为控制臂。在基线和6周后收集血液样本，和各种自我报告的压力测量，在基线时收集身体和情绪健康，6周后,12周后。在基线和6周后进行全血的全转录组mRNA测序，同时测量血浆IL-6，IL-8，IL-10，TNF-α，和IFN-γ。分离外周血单核细胞，并测定端粒酶活性。在基线和6周后评估昼夜唾液皮质醇谱。主要结果是一组预先确定的53个基因随时间的变化，这些基因代表了与压力有关的免疫相关变化。这是使用混合线性模型进行分析的。次要结果包括上述所有其他自我报告的测量和生物标志物。
未经评估：共有61名护士被随机分配，52有足够的数据包括在最终分析中。6周后,对照组的护士报告了通过感知压力量表测量的压力显着降低，而正念组的护士则没有。然而,12周后,正念组的压力也显著减少。与对照组相比，在参与正念计划的护士中,未观察到RNA基因表达或任何其他生物标志物的显著变化.
UNASSIGNED：我们的研究发现，这种简短的基于在线正念的干预措施可以有效地减轻护士的压力，尽管与听轻松的音乐相比有延迟的效果。关于免疫调节作用，治疗组和对照组在转录组或其他免疫功能检测生物标志物方面没有显著差异.这项研究为正念对免疫功能的转录和循环生物标志物的影响提供了证据。
