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Abstract：
Neurodegenerative diseases are a class of incurable and debilitating diseases characterized by progressive degeneration and death of cells in the central nervous system. They have multiple underlying mechanisms; however, they all share common degenerative features, such as mitochondrial dysfunction. According to recent studies, neurodegenerative diseases are associated with the accumulation of dysfunctional mitochondria. Selective autophagy of mitochondria, called mitophagy, can specifically degrade excess or dysfunctional mitochondria within cells. In this review, we highlight recent findings on the role of mitophagy in neurodegenerative disorders. Multiple studies were collected, including those related to the importance of mitochondria, the mechanism of mitophagy in protecting mitochondrial health, and canonical and non-canonical pathways in mitophagy. This review elucidated the important function of mitophagy in neurodegenerative diseases, discussed the research progress of mitophagy in neurodegenerative diseases, and summarized the role of mitophagy-related proteins in neurological diseases. In addition, we also highlight pharmacological advances in neurodegeneration.
摘要：
神经退行性疾病是一类无法治愈和衰弱的疾病，其特征是中枢神经系统中细胞的进行性变性和死亡。它们有多种潜在机制；然而，它们都有共同的退化特征，如线粒体功能障碍。根据最近的研究，神经退行性疾病与功能失调的线粒体的积累有关。线粒体的选择性自噬，称为线粒体自噬，可以特异性降解细胞内过量或功能失调的线粒体。在这次审查中,我们强调了最近发现的线粒体自噬在神经退行性疾病中的作用。收集了多项研究，包括那些与线粒体的重要性有关的，线粒体自噬保护线粒体健康的机制，以及有丝分裂中的规范和非规范途径。本文综述了线粒体自噬在神经退行性疾病中的重要作用。讨论了线粒体自噬在神经退行性疾病中的研究进展，综述了线粒体自噬相关蛋白在神经系统疾病中的作用。此外,我们还强调了神经变性的药理学进展。
