PDF(Pubmed)
Abstract：
UNASSIGNED: A subsequent cardiac toxicity is deemed to be dose-dependent for left-sided breast cancer irradiation. This study aims to demonstrate the effect of respiratory capacity for dose sparing when the deep inspiration breath hold with Active Breathing Coordinator technique (ABC-DIBH) is used in left-sided breast cancer irradiation.
UNASSIGNED: 74 left-sided breast cancer patients, who received whole breast or post-mastectomy chest wall radiotherapy with ABC-DIBH between 2020 and 2021 in our center, were retrospectively reviewed in this study. CT scans of free breath (FB) and ABC-DIBH were done for each patient, and two treatment plans with a prescription dose of 5000 cGy/25 Fr were designed separately. The dose to heart, left anterior descending artery (LAD) and lungs was compared between FB and ABC-DIBH. The correlation between individual parameters (dose to organs at risk (OARs) and minimum heart distance (MHD)) was analyzed, and the effect of respiratory capacity for dose sparing was assessed.
UNASSIGNED: The plans with ABC-DIBH achieved lower Dmean for heart (34.80%, P < 0.01) and LAD (29.33%, P < 0.01) than those with FB. Regression analysis revealed that both Dmean and D2 of heart were negatively correlated with MHD in the plans with FB and ABC-DIBH, which decreased with the increase in MHD by 37.8 cGy and 309.9 cGy per 1mm, respectively. Besides, a lower Dmean of heart was related to a larger volume of ipsilateral lung in plans with FB. With the increase in volume of ipsilateral lung, the linear correlation was getting weaker and weaker until the volume of ipsilateral lung reached 1700 cc. Meanwhile, a negative linear correlation between Dmean of LAD and MHD in plans with FB and ABC-DIBH was observed, whose slope was 162.5 and 135.9 cGy/mm, respectively. Furthermore, when the respiratory capacity of ABC-DIBH reached 1L, and the relative ratio (ABC-DIBH/FB) reached 3.6, patients could obtain the benefit of dose sparing. The larger difference in respiratory capacity had no significant effect in the larger difference of MHD, Dmean of heart and Dmean of LAD between FB and ABC-DIBH.
UNASSIGNED: This study demonstrates the sufficiently good effect of ABC-DIBH when utilizing for cardiac sparing. It also reveals the correlations among individual parameters and the effect of respiratory capacity for dose sparing. This helps take optimal advantage of the ABC-DIBH technique and predict clinical benefits.
UNASSIGNED: 74 left-sided breast cancer patients, who received whole breast or post-mastectomy chest wall radiotherapy with ABC-DIBH between 2020 and 2021 in our center, were retrospectively reviewed in this study. CT scans of free breath (FB) and ABC-DIBH were done for each patient, and two treatment plans with a prescription dose of 5000 cGy/25 Fr were designed separately. The dose to heart, left anterior descending artery (LAD) and lungs was compared between FB and ABC-DIBH. The correlation between individual parameters (dose to organs at risk (OARs) and minimum heart distance (MHD)) was analyzed, and the effect of respiratory capacity for dose sparing was assessed.
UNASSIGNED: The plans with ABC-DIBH achieved lower Dmean for heart (34.80%, P < 0.01) and LAD (29.33%, P < 0.01) than those with FB. Regression analysis revealed that both Dmean and D2 of heart were negatively correlated with MHD in the plans with FB and ABC-DIBH, which decreased with the increase in MHD by 37.8 cGy and 309.9 cGy per 1mm, respectively. Besides, a lower Dmean of heart was related to a larger volume of ipsilateral lung in plans with FB. With the increase in volume of ipsilateral lung, the linear correlation was getting weaker and weaker until the volume of ipsilateral lung reached 1700 cc. Meanwhile, a negative linear correlation between Dmean of LAD and MHD in plans with FB and ABC-DIBH was observed, whose slope was 162.5 and 135.9 cGy/mm, respectively. Furthermore, when the respiratory capacity of ABC-DIBH reached 1L, and the relative ratio (ABC-DIBH/FB) reached 3.6, patients could obtain the benefit of dose sparing. The larger difference in respiratory capacity had no significant effect in the larger difference of MHD, Dmean of heart and Dmean of LAD between FB and ABC-DIBH.
UNASSIGNED: This study demonstrates the sufficiently good effect of ABC-DIBH when utilizing for cardiac sparing. It also reveals the correlations among individual parameters and the effect of respiratory capacity for dose sparing. This helps take optimal advantage of the ABC-DIBH technique and predict clinical benefits.
摘要：
未经批准：对于左侧乳腺癌照射，随后的心脏毒性被认为是剂量依赖性的。这项研究旨在证明在左侧乳腺癌照射中使用主动呼吸协调员技术（ABC-DIBH）进行深吸气屏住呼吸时，呼吸能力对剂量节省的影响。
未经证实：74例左侧乳腺癌患者，在我们中心的2020年至2021年期间接受了全乳或乳房切除术后胸壁放疗的ABC-DIBH，在这项研究中进行了回顾性回顾。对每位患者进行自由呼吸（FB）和ABC-DIBH的CT扫描，并分别设计了两种处方剂量为5000cGy/25Fr的治疗方案。心脏的剂量，比较FB和ABC-DIBH的左前降支（LAD）和肺。分析了个体参数（对危险器官的剂量（OAR）和最小心脏距离（MHD））之间的相关性，并评估了呼吸能力对剂量节约的影响。
未经批准：ABC-DIBH的计划降低了心脏的Dmean（34.80％，P<0.01)和LAD(29.33%，P<0.01）比FB。回归分析显示，在FB和ABC-DIBH的计划中，心脏的Dmean和D2与MHD呈负相关。随着MHD每1mm增加37.8cGy和309.9cGy，分别。此外,在FB计划中，心脏的Dmean较低与同侧肺的体积较大有关。随着同侧肺容积的增加,线性相关性越来越弱，直到同侧肺体积达到1700cc。同时,在有FB和ABC-DIBH的计划中，LAD的Dmean和MHD之间呈负线性相关，斜率为162.5和135.9cGy/mm，分别。此外，当ABC-DIBH的呼吸容量达到1L时，相对比值（ABC-DIBH/FB）达到3.6，患者可获得节省剂量的益处。呼吸容量的较大差异对MHD的较大差异无显著影响，FB和ABC-DIBH之间的心脏Dmean和LADDmean。
未经证实：本研究证明了ABC-DIBH在用于心脏保护时具有足够好的效果。它还揭示了各个参数之间的相关性以及呼吸能力对剂量节约的影响。这有助于最佳利用ABC-DIBH技术并预测临床益处。
未经证实：74例左侧乳腺癌患者，在我们中心的2020年至2021年期间接受了全乳或乳房切除术后胸壁放疗的ABC-DIBH，在这项研究中进行了回顾性回顾。对每位患者进行自由呼吸（FB）和ABC-DIBH的CT扫描，并分别设计了两种处方剂量为5000cGy/25Fr的治疗方案。心脏的剂量，比较FB和ABC-DIBH的左前降支（LAD）和肺。分析了个体参数（对危险器官的剂量（OAR）和最小心脏距离（MHD））之间的相关性，并评估了呼吸能力对剂量节约的影响。
未经批准：ABC-DIBH的计划降低了心脏的Dmean（34.80％，P<0.01)和LAD(29.33%，P<0.01）比FB。回归分析显示，在FB和ABC-DIBH的计划中，心脏的Dmean和D2与MHD呈负相关。随着MHD每1mm增加37.8cGy和309.9cGy，分别。此外,在FB计划中，心脏的Dmean较低与同侧肺的体积较大有关。随着同侧肺容积的增加,线性相关性越来越弱，直到同侧肺体积达到1700cc。同时,在有FB和ABC-DIBH的计划中，LAD的Dmean和MHD之间呈负线性相关，斜率为162.5和135.9cGy/mm，分别。此外，当ABC-DIBH的呼吸容量达到1L时，相对比值（ABC-DIBH/FB）达到3.6，患者可获得节省剂量的益处。呼吸容量的较大差异对MHD的较大差异无显著影响，FB和ABC-DIBH之间的心脏Dmean和LADDmean。
未经证实：本研究证明了ABC-DIBH在用于心脏保护时具有足够好的效果。它还揭示了各个参数之间的相关性以及呼吸能力对剂量节约的影响。这有助于最佳利用ABC-DIBH技术并预测临床益处。
